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PPP6C
This gene encodes the catalytic subunit of protein phosphatase, a component of a signaling pathway regulating cell cycle progression. Splice variants encoding different protein isoforms exist. The pseudogene of this gene is located on chromosome X.
Protein class
Cancer-related genes, Enzymes, Metabolic proteins
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS) (PubMed:18186651). Interacts with subunits PPP6R1, PPP6R2 and PPP6R3 (PubMed:16769727, 18186651). Interacts with subunit ANKRD28 (PubMed:18186651). Interacts with IGBP1 (PubMed:9647778). Interacts with MAP3K7 (PubMed:17079228). Interacts with NFKBIE (PubMed:16769727). Interacts with TRIM14 and WRNIP1; these interactions positively regulate the RIG-I/DDX58 signaling pathway (PubMed:29053956).
Molecular function
Hydrolase, Protein phosphatase
More Types Infomation
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, ICC, IP
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For Research Use Only. Not For Clinical Use.