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SERPINB4
The protein encoded by this gene is a member of the serpin family of serine protease inhibitors. The encoded protein is highly expressed in many tumor cells and can inactivate granzyme M, an enzyme that kills tumor cells. This protein, along with serpin B3, can be processed into smaller fragments that aggregate to form an autoantigen in psoriasis, probably by causing chronic inflammation. [provided by RefSeq, Jan 2017]
Protein class
Cancer-related genes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enriched (Basal respiratory cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (HaCaT, HSkMC, SiHa, U-2197)
Molecular function
Protease inhibitor, Serine protease inhibitor
More Types Infomation
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IHC
-
- Species Reactivity: Human
- Type: IgG
- Application: IHC-P
-
- Species Reactivity: Human
- Application: ELISA, WB
- Recombinant Mouse Anti-SERPINB4 Antibody (VS-0923-FY133) (VS-0923-FY133)
-
- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: ELISA, WB
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For Research Use Only. Not For Clinical Use.