Plasma proteins
Intracellular
Low cell type specificity
Low immune cell specificity
Low cell line specificity
May form homooligomers (PubMed:20930030). Associated component of the telomerase holoenzyme complex (PubMed:19179534). Interacts with TERT, independently of the telomerase RNA (PubMed:12676087, PubMed:12699629). Interacts with SMG1, SMG5, SMG7, UPF1, UPF2, UPF3B and the PP2A catalytic subunits (PubMed:12554878, PubMed:19060897, PubMed:20930030). Also interacts with the exon junction complex (EJC) composed at least of CASC3, EIF4A3, MAGOH and RBM8A; required for the process of nonsense-mediated mRNA decay (PubMed:20930030). Interacts with DHX34; the interaction is RNA-independent (PubMed:25220460).
DNA-binding, Endonuclease, Hydrolase, Nuclease
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For Research Use Only. Not For Clinical Use.