Intracellular
Cell type enhanced (Proximal tubular cells)
Low immune cell specificity
Cell line enhanced (A549)
Component of the probable ECS(SPSB2) E3 ubiquitin-protein ligase complex which contains CUL5, RNF7/RBX2, Elongin BC complex and SPSB2 (PubMed:15601820). Interacts with CUL5, RNF7, ELOB and ELOC (PubMed:15601820). Interacts with MET (PubMed:15713673). Interacts (via B30. 2/SPRY domain) with PAWR; this interaction occurs in association with the Elongin BC complex (PubMed:16498413, PubMed:20561531). Interacts with NOS2 (PubMed:21199876). (Microbial infection) Interacts (via C-terminus) with HCV envelope glycoprotein E1. Interacts (via C-terminus) with HCV non-structural protein 5A; this interaction targets NS5A for ubiquitination and degradation.
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For Research Use Only. Not For Clinical Use.