FDA approved drug targets
Membrane
Cell type enhanced (Bipolar cells, Inhibitory neurons, Horizontal cells, Excitatory neurons)
Not detected in immune cells
Cell line enhanced (NTERA-2)
Interacts with SYT1/synaptotagmin-1 in a calcium-dependent manner. Binds the adapter protein complex AP-2 (By similarity). (Microbial infection) Interacts with C. botulinum neurotoxin type A2 (BoNT/A, botA) (PubMed:29649119). Interaction is improved by glycosylation of SV2 (PubMed:29649119).
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For Research Use Only. Not For Clinical Use.