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TAOK3
The protein encoded by this gene is a serine/threonine protein kinase that activates the p38/MAPK14 stress-activated MAPK cascade but inhibits the basal activity of the MAPK8/JNK cascade. The encoded protein is a member of the GCK subfamily of STE20-like kinases. [provided by RefSeq, Oct 2016]
Protein class
Enzymes, Metabolic proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Oligodendrocyte precursor cells, Rod photoreceptor cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (HMC-1)
Interaction
Self-associates. Interacts with ERN1 and TRAF2. Interaction with TRAF2 is facilitated under ER stress conditions, such as treatment with tunicamycin, and may promote TRAF2 phosphorylation.
Molecular function
Kinase, Serine/threonine-protein kinase, Transferase
More Types Infomation
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- Derivation: Phage display library screening
- Species Reactivity: Mouse, Rat, Human
- Type: IgG
- Application: WB, IHC-P
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- Species Reactivity: Human
- Application: WB
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For Research Use Only. Not For Clinical Use.