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TCP1
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, three pseudogenes that appear to be derived from this gene have been found.
Protein class
Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Late spermatids)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Component of the chaperonin-containing T-complex (TRiC), a heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter (PubMed:1630492, PubMed:20080638, PubMed:25467444). Interacts with PACRG (PubMed:14532270). Interacts with GBA (PubMed:21098288). Interacts with DLEC1 (PubMed:33144677).
Molecular function
Chaperone
More Types Infomation
- APC-B*07:02/Human TCP1 (QPRYPVNSV) MHC Tetramer (MHC-LC2093)
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- Class: Class I
- Antigen: TCP1
- Antigen Species: Human
- Peptide: QPRYPVNSV
- Conjugate: APC
- PE-B*07:02/Human TCP1 (QPRYPVNSV) MHC Tetramer (MHC-LC2092)
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- Class: Class I
- Antigen: TCP1
- Antigen Species: Human
- Peptide: QPRYPVNSV
- Conjugate: PE
-
- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ICC, IHC-P, IP, WB
- Recombinant Mouse Anti-Human TCP1 Antibody (MOB-1916MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: IHC-P, WB
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ICC, IF, IP
-
- Species Reactivity: Human, Hamster
- Type: Rabbit IgG
- Application: WB, IHC-Fr, IHC-P, IF, IP
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For Research Use Only. Not For Clinical Use.