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TRAF4
This gene encodes a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. The encoded protein has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined.
Protein class
Cancer-related genes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Urothelial cells)
Immune cell specificity
Immune cell enriched (plasmacytoid DC)
Cell line specificity
Low cell line specificity
Interaction
Homotrimer (Probable). Interacts with LTBR/TNFRSF3, NGFR/TNFRSF16, RPS6KB1 and TGFB1I1. Interacts with SMURF1. Interacts (via TRAF domain) with MAP3K4 (via kinase domain). Interacts with NCF1, TICAM1, IRAK1 and TRAF6, and is probably part of a complex containing TRAF4, NCF1, TICAM1, IRAK1 and TRAF6. Interacts (via MATH domain) with GP6 and GP1BB (PubMed:20946164, PubMed:29073066). Interacts with EGFR (via C-terminal region); this interaction promotes the formation of EGFR asymmetric dimers (PubMed:30352854). Interacts with PKM; this interaction promotes PKM kinase activity (PubMed:32268273).
Molecular function
Developmental protein
More Types Infomation
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: FC, ICC, WB
- Recombinant Mouse Anti-Human TRAF4 Antibody (MOB-0835MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: IHC-P
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For Research Use Only. Not For Clinical Use.