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TRIM16

The protein encoded by this gene is a tripartite motif (TRIM) family member that contains two B box domains and a coiled-coiled region that are characteristic of the B box zinc finger protein family. While it lacks a RING domain found in other TRIM proteins, the encoded protein can homodimerize or heterodimerize with other TRIM proteins and has E3 ubiquitin ligase activity. This gene is also a tumor suppressor and is involved in secretory autophagy.
Protein class

Enzymes

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Pancreatic endocrine cells, Urothelial cells, Squamous epithelial cells)

Immune cell specificity

Immune cell enriched (T-reg)

Cell line specificity

Cell line enhanced (A549, HaCaT, HeLa, OE19)

Interaction

Homodimerizes via its coiled-coil domain. Heterodimerizes with MID1, TRIM24 and PML. Interacts with Galectin-3/LGALS3 in a ULK1-dependent manner; this interaction mediates autophagy of damage endomembranes. Interacts with BECN1. Interacts with ATG16L1. Interacts with p62/SQSTM and LC3B/MAP1LC3B.

Molecular function

Transferase

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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