Enzymes
Intracellular
Cell type enhanced (Pancreatic endocrine cells, Urothelial cells, Squamous epithelial cells)
Immune cell enriched (T-reg)
Cell line enhanced (A549, HaCaT, HeLa, OE19)
Homodimerizes via its coiled-coil domain. Heterodimerizes with MID1, TRIM24 and PML. Interacts with Galectin-3/LGALS3 in a ULK1-dependent manner; this interaction mediates autophagy of damage endomembranes. Interacts with BECN1. Interacts with ATG16L1. Interacts with p62/SQSTM and LC3B/MAP1LC3B.
Transferase
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For Research Use Only. Not For Clinical Use.