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WTAP
The Wilms tumor suppressor gene WT1 appears to play a role in both transcriptional and posttranscriptional regulation of certain cellular genes. This gene encodes a WT1-associating protein, which is a ubiquitously expressed nuclear protein. Like WT1 protein, this protein is localized throughout the nucleoplasm as well as in speckles and partially colocalizes with splicing factors. Alternative splicing of this gene results in several transcript variants encoding three different isoforms.
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Langerhans cells, Suprabasal keratinocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Component of the WMM complex, a N6-methyltransferase complex composed of a catalytic subcomplex, named MAC, and of an associated subcomplex, named MACOM (PubMed:24407421, PubMed:24981863, PubMed:24316715, PubMed:29507755, PubMed:29506078, PubMed:29348140). The MAC subcomplex is composed of METTL3 and METTL14 (PubMed:29507755). The MACOM subcomplex is composed of WTAP, ZC3H13, CBLL1/HAKAI, VIRMA, and, in some cases of RBM15 (RBM15 or RBM15B) (PubMed:29507755). Interacts with WT1 (PubMed:11001926, PubMed:17095724). Also component of a MACOM-like complex, named WTAP complex, composed of WTAP, ZC3H13, CBLL1, VIRMA, RBM15, BCLAF1 and THRAP3 (PubMed:24100041).
Molecular function
Developmental protein
More Types Infomation
- Mouse Anti-WTAP Recombinant Antibody (clone 7H10B4) (VS3-XY1605)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, IHC, FC
- Mouse Anti-WTAP Recombinant Antibody (clone 3G4B6) (VS3-XY1604)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, IHC, FC, ICC
- Mouse Anti-WTAP Recombinant Antibody (clone 3B6B11) (VS3-XY1603)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, IHC, FC
- Mouse Anti-WTAP Recombinant Antibody (clone 1B3C7) (VS3-XY1602)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, IHC, FC, ICC
- Chicken Anti-WTAP Polyclonal IgY (BRD-0631MZ)
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- Species Reactivity: Human, Mouse, Rat
- Type: Chicken antibody
- Application: WB
- Mouse Anti-WTAP Recombinant Antibody (clone B6-B6) (VS3-QX1249)
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- Derivation: Mouse
- Species Reactivity: Human, Monkey
- Type: Mouse IgG1
- Application: WB, ICC, IHC, FC
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For Research Use Only. Not For Clinical Use.