Rat Anti-CD8αβ Recombinant Antibody (clone YTS156.7.7) (CAT#: PABC-088)
Recombinant Rat Antibody (YTS156. 7. 7) is capable of binding to Mouse CD8αβ, expressed in Chinese Hamster Ovary cells (CHO). The YTS156. 7 mAb inhibits this interaction and blocks T cell activation.
Specific Inquiry
Neut
Figure 1 Rat Anti-CD8αβ Antibody (clone YTS156.7.7) in Neut.
YTS156.7.7, but not YTS105.18, blocks MHC class I and CD8 interaction and subsequent T cell activation. Ca 2+ mobilization in OT-I RAG− splenocytes treated with H-2Kb tetramers loaded with the OVA peptide (H-2Kb/OVA) after pre-staining with mAbs 53.6.7 (red line), YTS105.18 (purple line) or YTS156.7.7 (green line).
Shore, D. A., Issafras, H., Landais, E., Teyton, L., & Wilson, I. A. (2008). The crystal structure of CD8 in complex with YTS156. 7.7 Fab and interaction with other CD8 antibodies define the binding mode of CD8 αβ to MHC class I. Journal of molecular biology, 384(5), 1190-1202.
Specifications
- Immunogen
- Mouse Ccluster of differentiation 8
- Host Species
- Rat
- Type
- Rat IgG
- Specificity
- Mouse CD8αβ
- Species Reactivity
- Mouse
- Clone
- YTS156.7.7
- Applications
- Block
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- CD8; cluster of differentiation 8; CD8αβ
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone YTS156.7.7"
See other products for "CD8αβ"
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBC-088 | Rat Anti-CD8αβ Recombinant Antibody (clone YTS156.7.7); Fab Fragment | Block | Rat Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBC-088 | Rat Anti-CD8αβ Recombinant Antibody (clone YTS156.7.7); scFv Fragment | Block | Rat scFv |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for PABC-088. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.