Recombinant Chimeric monoclonal antibody expressed in CHO binding to Human FZD10. OTSA101 is an antibody drug targets a novel tumor-specific antigen FZD10 (Frizzled homolog 10), used for cancer therapy, has conducted phase I clinical trial for synovial sarcoma, which is a type of soft tissue sarcoma.
Figure 1 Therapeutic results of radioimmunotherapy (RIT) with ²¹¹AtOTSA101 in the synovial sarcoma (SS) subcutaneous xenograft mouse model.
Changes in tumor volumes in the model mice after RIT with ²¹¹At-OTSA101. Plots were interrupted if the animal reached the defined endpoint. Five mice were enrolled in each of the treatment groups, except for the intact IgG control (4 mice).
Li, H. K., Sugyo, A., Tsuji, A. B., Morokoshi, Y., Minegishi, K., Nagatsu, K., ... & Nakamura, Y. (2018). α‐particle therapy for synovial sarcoma in the mouse using an astatine‐211‐labeled antibody against frizzled homolog 10. Cancer science, 109(7), 2302-2309.
Figure 2 Histopathological analyses of the synovial sarcoma (SS) xenografts by immunohistochemistry and H&E staining.
CD31 corresponding H&E staining at day 1 after ²¹¹At-OTSA101 treatment. Scale bars, 50 μm
Li, H. K., Sugyo, A., Tsuji, A. B., Morokoshi, Y., Minegishi, K., Nagatsu, K., ... & Nakamura, Y. (2018). α‐particle therapy for synovial sarcoma in the mouse using an astatine‐211‐labeled antibody against frizzled homolog 10. Cancer science, 109(7), 2302-2309.
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• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
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CAT | Product Name | Application | Type |
---|---|---|---|
MOB-2133z | Mouse Anti-FZD10 Recombinant Antibody (MOB-2133z) | IHC, ELISA, IF, IP, FC | Mouse IgG |
HPAB-0028LY | Mouse Anti-FZD10 Recombinant Antibody (HPAB-0028LY) | WB | Mouse IgG |
VS-0723-WK82 | Human Anti-FZD10 Recombinant Antibody (VS-0723-WK82) | FC | Chimeric (rabbit/human) IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-2133z-F(E) | Recombinant Anti-Human FZD10 Antibody Fab Fragment | WB, IF, FuncS | Fab |
HPAB-0028LY-F(E) | Mouse Anti-FZD10 Recombinant Antibody; Fab Fragment (HPAB-0028LY-F(E)) | WB | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-2133z-S(P) | Recombinant Anti-Human FZD10 Antibody scFv Fragment | RIA, ELISA, FuncS | scFv |
HPAB-0028LY-S(P) | Mouse Anti-FZD10 Recombinant Antibody; scFv Fragment (HPAB-0028LY-S(P)) | WB | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-030CQ-S(P) | Human Anti-FZD10 Recombinant Antibody; scFv Fragment (TAB-030CQ-S(P)) | ELISA, FC, WB, Block | Humanized scFv |
TAB-030CQ-F(E) | Human Anti-FZD10 Recombinant Antibody; Fab Fragment (TAB-030CQ-F(E)) | ELISA, FC, WB, Block | Humanized Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-031CQ-S(P) | Mouse Anti-FZD10 Recombinant Antibody; scFv Fragment (TAB-031CQ-S(P)) | ELISA, FC, WB, Block | Mouse scFv |
TAB-032CQ-S(P) | Mouse Anti-FZD10 Recombinant Antibody; scFv Fragment (TAB-032CQ-S(P)) | ELISA, FC, WB, Block | Mouse scFv |
TAB-031CQ-F(E) | Human Anti-FZD10 Recombinant Antibody; Fab Fragment (TAB-031CQ-F(E)) | ELISA, FC, WB, Block | Chimeric (mouse/human) Fab |
TAB-032CQ-F(E) | Human Anti-FZD10 Recombinant Antibody; Fab Fragment (TAB-032CQ-F(E)) | ELISA, FC, WB, Block | Chimeric (mouse/human) Fab |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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