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Anti-GPA33 immunotoxin (scFv)-α-sar (CAT#: AGTO-G034F)

This immunotoxin was achieved by conjugating/fusing the Anti-GPA33 scFv to α-sarcin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to GPA33 tumor antigen expressing cells. Once bind, alpha-Sarcin enters into the cells by receptor-mediated endocytosis and interacts with a single bond in the targeted ribosome and breaks it, causing the ribosome to be inactivated. It was designed for treatment of colon cancer.


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Normal Tissue
Figure 1 High expression in colon
Figure 1 High expression in colon

* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18858/ihc_selected.jpg
Figure 2 Low expression in liver
Figure 2 Low expression in liver

* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18858/43100_A_7_4_val_selected.jpg
Figure 3 Colon
Figure 3 Colon
(Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: High Intensity: Strong Quantity:>75% Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18858/43100_A_9_3.jpg
Figure 4 Appendix
Figure 4 Appendix
(Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: High Intensity: Strong Quantity: 75%-25% Enterocytes - Gradient Gradient: Ascending Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18858/43100_A_2_2.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enriched (OE19)
Figure 5 RNA cell line category: Cell line enriched (OE19)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000143167-GPA33

Specifications

  • Host Species
  • Mouse
  • Species Reactivity
  • Human
  • Molecule Class
  • scFv-α-sar
  • Toxin Description
  • Alpha-Sarcin is a ribosome-inactivating protein produced in the mold Aspergillus giganteus. Specifically, alpha-sarcin cleaves the a portion of ribosomal RNA that forms the small ribosomal substrate. The high specificity of alpha-sarcin and its efficiency of cleavage are point of study and also account for this protein's very high toxicity level.
  • Applications
  • This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
  • Related Disease
  • colon cancer

Target

  • Alternative Names
  • GPA33; glycoprotein A33 (transmembrane); A33; cell surface A33 antigen; transmembrane glycoprotein A33; α-sar; α-sarcin

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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See other products for "GPA33"

Recombinant Antibody

CAT Product Name Application Type
MOB-2119z Mouse Anti-GPA33 Recombinant Antibody (MOB-2119z) IHC, WB Mouse IgG1
MOB-069LC Rat Anti-GPA33 Recombinant Antibody (clone YC069) ELISA, FC, WB Rat IgG
HPAB-0521-YJ Human Anti-GPA33 Recombinant Antibody (HPAB-0521-YJ) WB, IP, FC, ELISA, FuncS Chimeric (Mouse/Human) IgG
HPAB-0522-YJ Human Anti-GPA33 Recombinant Antibody (HPAB-0522-YJ) WB, IP, FC, ELISA, FuncS Humanized IgG
VS3-WK386 Rabbit Anti-GPA33 Recombinant Antibody (clone JE49-54) WB, IHC, IP Rabbit IgG

Fab Fragment Antibody

CAT Product Name Application Type
MOB-2119z-F(E) Recombinant Anti-Human GPA33 Antibody Fab Fragment FC, WB, FuncS Fab
HPAB-1717-FY-S(P) Human Anti-GPA33 Recombinant Antibody (clone 263A17); Fab Fragment ELISA Human Fab
HPAB-0521-YJ-F(E) Human Anti-GPA33 Recombinant Antibody; Fab Fragment (HPAB-0521-YJ-F(E)) WB, IP, FC, ELISA, FuncS Chimeric (Mouse/Human) Fab
HPAB-0522-YJ-F(E) Human Anti-GPA33 Recombinant Antibody; Fab Fragment (HPAB-0522-YJ-F(E)) WB, IP, FC, ELISA, FuncS Humanized Fab
FAMAB-0161WJ-F(E) Human Anti-GPA33 Recombinant Antibody (clone A2); Fab Fragment ELISA, WB, FC, IF Human Fab

scFv Fragment Antibody

CAT Product Name Application Type
MOB-2119z-S(P) Recombinant Anti-Human GPA33 Antibody scFv Fragment WB, FC, FuncS scFv
HPAB-1717-FY-F(E) Human Anti-GPA33 Recombinant Antibody (clone 263A17); scFv Fragment ELISA Human scFv
HPAB-0521-YJ-S(P) Human Anti-GPA33 Recombinant Antibody; scFv Fragment (HPAB-0521-YJ-S(P)) WB, IP, FC, ELISA, FuncS Human scFv
HPAB-0522-YJ-S(P) Human Anti-GPA33 Recombinant Antibody; scFv Fragment (HPAB-0522-YJ-S(P)) WB, IP, FC, ELISA, FuncS Human scFv
FAMAB-0161WJ-S(P) Human Anti-GPA33 Recombinant Antibody (clone A2); scFv Fragment ELISA, WB, FC, IF Human scFv

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-1485 Hi-Affi™ Rabbit Anti-GPA33 Recombinant Antibody (clone DS1485AB) IHC-P, IP, WB Rabbit IgG

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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