Products

Anti-EGFR × Anti-ErbB-3 Bispecific Antibody (F(ab`)2, PB4522) (FAB-MZ007)

This bispecific antibody comprising a first antigen-binding site that binds EGFR and a second antigen-binding site that binds ErbB-3 can inhibit the proliferation of pancreatic cancer cells. It is capable of induceing ADCC (Dependent cell-mediated cytotoxicity) activity towards the EGFR amplified cell line, which is an important anti-tumour mechanism of action for therapeutic antibodies in cancer.      

  • Datasheet

Specifications
Targets
EGFR & ErbB-3
Type
F(ab')2
Expression Host
CHO
Species Reactivity
Human
Target 1
EGFR
Host
Human
Target 2
ErbB-3
Host
Human
Purity
>95% judged by SDS-PAGE under reducing condition
Applications
FC, ADCC Reporter Bioassay
Related Disease
Pancreatic cancer
Targets
Target 1
EGFR
Gene ID
1956
UniProt ID
P00533
Alternative Names
EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2
Target 2
ErbB-3
Gene ID
2065
UniProt ID
P21860
Alternative Names
ERBB3; erb-b2 receptor tyrosine kinase 3; HER3; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3; receptor tyrosine-protein kinase erbB-3; proto-oncogene-like protein c-ErbB-3; human epidermal growth factor receptor 3; tyrosine kinase-type cell surface receptor HER3; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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