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EGFR & ErbB-3

Anti-EGFR & ErbB-3 Products

Anti-Human EGFR Recombinant Antibody (Cetuximab) (TAB-003)
- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
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Anti-EGFR Antibody-Cytokine Fusion Protein, IL2-IgG (mAb 425) (ACFP-SH078)
- Target: EGFR
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Mouse
- Cytokine 1 Species: Human
- Molecule Class: IL2-IgG2a
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Anti-Human EGFR Recombinant Antibody (TAB-119) (TAB-119)
- Derivation: Human
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: FC, IP, ELISA, Neut, FuncS, IF, WB
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Anti-Human EGFR Recombinant Antibody (Panitumumab) (TAB-020)
- Derivation: Human
- Species Reactivity: Human
- Type: IgG2 - kappa
- Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
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Anti-EGFR Recombinant Antibody (Imgatuzumab) (TAB-753)
- Derivation: Humanized (from rat)
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: Neut, ELISA, IF, IP, FuncS, FC, WB
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Anti-Human EGFR Recombinant Antibody (Modotuximab) (TAB-H49)
- Derivation: Chimeric
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: FuncS, IF, Neut, ELISA, FC, IP, IHC
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Anti-EGFR Recombinant Antibody (Nimotuzumab) (TAB-710)
- Derivation: Humanized (from mouse)
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: ELISA, IP, FC, FuncS, Neut, IF, IHC
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Recombinant Human Anti-EGFR Antibody (PABX-052) (PABX-052)
- Derivation: Human
- Species Reactivity: Human
- Type: IgG
- Application: WB, ELISA, FuncS, IB, FC, SPR, Apop
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Mouse Anti-EGFR Recombinant Antibody (clone 7A7) (PABW-088)
- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, WB
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Anti-Human EGFR Recombinant Antibody (ABT-806) (TAB-228CL)
- Derivation: Humanized
- Species Reactivity: Human
- Type: Antibody
- Application: WB, IHC
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Mouse Anti-EGFR Recombinant Antibody (TAB-271MZ) (TAB-271MZ)
- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: FuncS
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Anti-Human EGFR Recombinant Antibody (TAB-014MZ-VHH) (TAB-014MZ-VHH)
- Type: Single domain antibody
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Human Anti-EGFR Recombinant Antibody (PABL-463) (PABL-463)
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized IgG
- Application: ELISA, WB, FuncS
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Recombinant Human Anti-EGFR Antibody Fab Fragment (PABX-053-F (E)) (PABX-053-F (E))
- Derivation: Human
- Species Reactivity: Human
- Type: Fab
- Application: WB, ELISA, FuncS
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Mouse Anti-EGFR Recombinant Antibody (PABW-171) (PABW-171)
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB
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Human Anti-EGFR Recombinant Antibody (TAB-270MZ) (TAB-270MZ)
- Species Reactivity: Human
- Type: Human antibody
- Application: ELISA
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Human Anti-EGFR Recombinant Antibody (TAB-272MZ) (TAB-272MZ)
- Species Reactivity: Human
- Type: Chimeric (mouse/human) IgG
- Application: FuncS
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Human Anti-EGFR Recombinant Antibody (TAB-274MZ) (TAB-274MZ)
- Species Reactivity: Human
- Type: Humanized IgG
- Application: FC
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Human Anti-EGFR Recombinant Antibody; Fab Fragment (TAB-308MZ-F(E)) (TAB-308MZ-F(E))
- Species Reactivity: Human
- Type: Chimeric antibody (mouse/human)
- Application: ELISA, FC
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Human Anti-EGFR Recombinant Antibody (PABW-039) (PABW-039)
- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: Chimeric (mouse/human) IgG
- Application: FuncS
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Human Anti-EGFR Recombinant Antibody (clone MR1) (PABC-040)
- Species Reactivity: Human
- Type: Human IgG
- Application: Block
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Afuco™ Anti-Human EGFR ADCC Recombinant Antibody (ABT-806), ADCC Enhanced (AFC-216CL)
- Derivation: Humanized
- Species Reactivity: Human
- Type: ADCC enhanced antibody
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Recombinant Mouse Anti-EGFR Antibody Fab Fragment (Matuzumab) (PABX-051-F (E))
- Derivation: Human
- Species Reactivity: Human
- Type: Fab
- Application: WB, Neut, FuncS
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Anti-Human EGFR Recombinant Antibody (TAB-040) (TAB-040)
- Derivation: Human
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
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Recombinant Human Anti-EGFR Antibody Fab Fragment (PABX-052-F (E)) (PABX-052-F (E))
- Derivation: Human
- Species Reactivity: Human
- Type: Fab
- Application: WB, ELISA, FuncS
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Human Anti-EGFR Recombinant Antibody (clone C225) (PABL-462)
- Species Reactivity: Human
- Type: Human IgG
- Application: FC
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Recombinant Mouse Anti-EGFR Antibody (clone FGF-R2) (MOB-0094MZ)
- Species Reactivity: Human
- Type: Mouse antibody
- Application: ELISA, IHC-P, FC
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Anti-EGFR/HER1 Recombinant Antibody (TAB-750) (TAB-750)
- Derivation: Chimeric (Human/Mouse)
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: Neut, ELISA, IF, IP, FuncS, FC, WB
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Anti-Human EGFR Recombinant Antibody (Matuzumab) (TAB-165)
- Derivation: Humanized
- Species Reactivity: Human
- Type: IgG1
- Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
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Anti-Human EGFR Recombinant Antibody (Futuximab) (TAB-H35)
- Derivation: Chimeric (human/mouse)
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: IF, WB, Inhib
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Mouse Anti-EGFR Recombinant Antibody (clone 42C11) (MOB-1078z)
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, ELISA, FC, IF, IHC, FuncS
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Anti-Human EGFR Recombinant Antibody Fab Fragment (EG-19-11) (TAB-313MZ-F(E))
- Derivation: Library
- Type: Human antibody
- Application: ELISA, FC
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Human Anti-EGFR Recombinant Antibody (HPAB-0136-YJ) (HPAB-0136-YJ)
- Species Reactivity: Human
- Type: Human IgG1
- Application: ELISA, FC, Inhib, FuncS
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Mouse Anti-EGFR Recombinant Antibody (clone mAb528) (PABZ-039)
- Species Reactivity: Human
- Type: Mouse IgG
- Application: FC
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Human Anti-EGFR Recombinant Antibody (HPAB-0060-WJ) (HPAB-0060-WJ)
- Species Reactivity: Human
- Type: Human IgG1, κ
- Application: ELISA, RIA, FC
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Rabbit Anti-Human EGFR (phospho Y1092) Antibody (MOB-0242MC)
- Species Reactivity: Rat, Human
- Application: IHC, WB
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Recombinant Human Anti-EGFR Antibody (Matuzumab) (PABX-051)
- Derivation: Human
- Species Reactivity: Human
- Type: IgG
- Application: WB, Neut, FuncS, FC, ELISA, IF, Inhib
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Anti-Human EGFR Recombinant Antibody Fab Fragment (L4-H3) (TAB-309MZ-F(E))
- Type: Humanized antibody
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Rabbit Anti-Human EGFR (phospho Y1068) Antibody (MOB-0243MC)
- Species Reactivity: Human, Mouse, Rat
- Application: IHC, WB
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Human Anti-EGFR Recombinant Antibody (TAB-278MZ) (TAB-278MZ)
- Species Reactivity: Human
- Type: Human IgG
- Application: Cyt, ELISA, Inhib
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Human Anti-EGFR Recombinant Antibody (TAB-279MZ) (TAB-279MZ)
- Species Reactivity: Human
- Type: Human IgG
- Application: Cyt, ELISA, Inhib
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Human Anti-EGFR Recombinant Antibody (clone P3X); Fab Fragment (HPAB-1445LY-F(E))
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, WB
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Mouse Anti-EGFR Recombinant Antibody (clone mAb528); scFv Fragment (PSBZ-039)
- Species Reactivity: Human
- Type: Mouse scFv
- Application: FC
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Mouse Anti-EGFR Recombinant Antibody; Fab Fragment (TAB-312MZ-F(E)) (TAB-312MZ-F(E))
- Species Reactivity: Human, Monkey
- Type: Mouse Fab
- Application: ELISA
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Human Anti-EGFR Recombinant Antibody (clone P2X); Fab Fragment (HPAB-1444LY-F(E))
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, WB
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Mouse Anti-EGFR Recombinant Antibody; Fab Fragment (TAB-311MZ-F(E)) (TAB-311MZ-F(E))
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
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Human Anti-EGFR Recombinant Antibody (clone MR1); Fab Fragment (PFBC-040)
- Species Reactivity: Human
- Type: Human Fab
- Application: Block
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Mouse Anti-EGFR Recombinant Antibody (clone mAb528); Fab Fragment (PFBZ-039)
- Species Reactivity: Human
- Type: Mouse Fab
- Application: FC
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Anti-Human EGFR Recombinant Antibody (LA22) (TAB-277MZ)
- Application: Cyt, FuncS
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Mouse Anti-EGFR Recombinant Antibody; Fab Fragment (TAB-307MZ-F(E)) (TAB-307MZ-F(E))
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC
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Mouse Anti-EGFR Recombinant Antibody; Fab Fragment (PFBW-171) (PFBW-171)
- Species Reactivity: Human
- Type: Mouse Fab
- Application: WB
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Human Anti-EGFR Recombinant Antibody (clone 25E); Fab Fragment (HPAB-1446LY-F(E))
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, WB
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Mouse Anti-EGFR Recombinant Antibody; Fab Fragment (TAB-310MZ-F(E)) (TAB-310MZ-F(E))
- Species Reactivity: Human, Monkey
- Type: Mouse Fab
- Application: ELISA
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Human Anti-EGFR Recombinant Antibody Fab Fragment (PFBW-039) (PFBW-039)
- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: Chimeric (mouse/human) Fab
- Application: FuncS
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Human Anti-EGFR Recombinant Antibody (clone C225); Fab Fragment (PFBL-459)
- Species Reactivity: Human
- Type: Human Fab
- Application: FC
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Human Anti-EGFR Recombinant Antibody (clone h-R3); Fab Fragment (PFBL-460)
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA, WB, FuncS
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Mouse Anti-EGFR Recombinant Antibody (TAB-0564CL) (TAB-0564CL)
- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA
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Mouse Anti-EGFR Recombinant Antibody (TAB-0565CL) (TAB-0565CL)
- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA
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Anti-EGFR Antibody-Cytokine Fusion Protein, IgG-IL2 (ACFP-SH155)
- Target: EGFR
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Humanized from Mouse
- Cytokine 1 Species: Human
- Molecule Class: IgG1-IL2
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Z-domain of protein A scaffold protein anti-Human EGFR (SZA-L219)
- Scaffold Name: Z-domain of protein A
- Target: EGFR
- Species Reactivity: Human
- Derivation: Phage display
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Human Anti-EGFR Recombinant Antibody (clone P1X); Fab Fragment (HPAB-1443LY-F(E))
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, WB
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Anti-Human EGFR Recombinant Antibody (LA1) (TAB-276MZ)
- Application: Cyt, FuncS
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Mouse Anti-EGFR Recombinant Antibody (TAB-275MZ) (TAB-275MZ)
- Species Reactivity: Human
- Type: Mouse IgG
- Application: Cyt, FuncS, Inhib
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Anti-Human EGFR Recombinant Antibody (TAB-015MZ-VHH) (TAB-015MZ-VHH)
- Type: Single domain antibody
- Application: sELISA
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Mouse Anti-EGFR Recombinant Antibody (TAB-273MZ) (TAB-273MZ)
- Species Reactivity: Human
- Type: Mouse IgG
- Application: FC, FuncS, IHC, IP, Inhib
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Anti-Human EGFR Recombinant Antibody (TAB-016MZ-VHH) (TAB-016MZ-VHH)
- Type: Single domain antibody
- Application: sELISA
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Mouse Anti-EGFR Recombinant Antibody; Fab Fragment (TAB-306MZ-F(E)) (TAB-306MZ-F(E))
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
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Human Anti-EGFR Recombinant Antibody; scFv Fragment (PSBL-080) (PSBL-080)
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, WB, FuncS
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Human Anti-EGFR Recombinant Antibody (clone h-R3); scFv Fragment (PSBL-460)
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: ELISA, WB, FuncS
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Anti-EGFR Antibody-Cytokine Fusion Protein, IgG (Ch225)-IL2 (ACFP-SH079)
- Target: EGFR
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Chimeric (Mouse-Human)
- Cytokine 1 Species: Human
- Molecule Class: IgG-IL2
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Human Anti-EGFR Recombinant Antibody; Fab Fragment (PFBL-080) (PFBL-080)
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, WB, FuncS
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Human Anti-EGFR Recombinant Antibody (clone C225); scFv Fragment (PSBL-459)
- Species Reactivity: Human
- Type: Human scFv
- Application: FC
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Anti-EGFR Antibody-Cytokine Fusion Protein, TNF-IgG (mAb 425) (ACFP-SH080)
- Target: EGFR
- Species Reactivity: Human
- Cytokine 1: TNFα
- Host: Mouse
- Cytokine 1 Species: Human
- Molecule Class: TNF-IgG2a
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Mouse Anti-EGFR Recombinant Antibody; Fab Fragment (TAB-0564CL-F(E)) (TAB-0564CL-F(E))
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
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Mouse Anti-EGFR Recombinant Antibody; Fab Fragment (TAB-0565CL-F(E)) (TAB-0565CL-F(E))
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
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Anti-EGFR-EDC/NHS-Dox ADC (ADC-058LZY)
- Target: EGFR
- Linker: EDC/NHS(1-ethyl-3-(3-diaminopropyl)carbodiimide/N-hydroxysuccinimide)
- Drug: doxorubicin
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Anti-EGFR-MCC-Dox ADC (ADC-057LZY)
- Target: EGFR
- Linker: MCC (4-(N-maleimidomethyl)cyclohexane-1-carboxylate)
- Drug: doxorubicin
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Hi-Affi™ Rabbit Anti-EGFR Recombinant Antibody (clone TH28DS) (MOR-4520)
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: IF, ICC, FC
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Anti-EGFRvIII-SMCC-DM1 ADC (ADC-048LZY)
- Target: EGFRvIII
- Linker: SMCC (N-succinimidyl-4-(N-maleimidomethyl)-cyclohexane-1-carboxylate)
- Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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Hi-Affi™ Rabbit Anti-EGFR Recombinant Antibody (clone TH82DS) (MOR-4570)
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA
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Hi-Affi™ Rabbit Anti-EGFR Recombinant Antibody (clone TH83DS) (MOR-4571)
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IF, ICC, FC
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Anti-EGFR-SMCC-methotrexate ADC (ADC-059LZY)
- Target: EGFR
- Linker: SMCC (N-succinimidyl-4-(N-maleimidomethyl)-cyclohexane-1-carboxylate)
- Drug: MTX
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Anti-EGFR (clone ABT-806)-mc-MMAF ADC (ADC-071LZY)
- Target: EGFR
- Linker: mc (maleimidocaproyl)
- Drug: MMAF (monomethyl auristatin F)
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Anti-EGFR-vc-Duostatin-3 ADC (ADC-088LZY)
- Target: EGFR
- Linker: VC (valine-citrulline)
- Drug: Duostatin-3
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Recombinant Anti-EGFR × Anti-ErbB-3 Bispecific Antibody (Fab₂, PB4522) (FAB-MZ007)
- Targets: EGFR & ErbB-3
- Type: Fab₂
- Application: FC, ADCC Reporter Bioassay
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Anti-EGFR-vc-PAB-MODO ADC (ADC-263CL)
- Target: epidermal growth factor receptor (EGFR)
- Linker: VC-PAB (valine-citrulline-p-aminobenzoyloxycarbonyl)
- Drug: MODO (monomethyldolastatin)
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Anti-EGFR (clone Antibody 1)-MC-MMAF ADC (ADC-059CL)
- Target: EGFR
- Linker: Mc (maleimidocaproyl)
- Drug: MMAF (Monomethyl auristatin F)
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Anti-EGFR (clone Bat0206)-SMCC-MDC ADC (ADC-158CL)
- Target: EGFR
- Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
- Drug: MDC (maytansinol)
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Anti-EGFR (MAb806)-SMCC-DM1 ADC (ADC-110LCT)
- Target: EGFR variant III
- Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
- Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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Anti-EGFR-doxorubicin ADC (ADC-168LZY)
- Target: EGFR
- Linker: polyethylene glycol linker
- Drug: doxorubicin
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Anti-EGFR (clone J2898A)-SMCC-DM1 ADC (ADC-047LZY)
- Target: EGFR
- Linker: SMCC (N-succinimidyl-4-(N-maleimidomethyl)-cyclohexane-1-carboxylate)
- Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
Compare

Anti-EGFR (ABT-806)-Mc-MMAE ADC (ABT-414) (ADC-L001)
- Target: EGFR
- Linker: Mc (maleimidocaproyl)
- Drug: MMAF (Monomethyl auristatin F)
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Anti-EGFR (J2898A)-SMCC-DM1 ADC (IMGN289) (ADC-L016)
- Target: EGFR
- Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
- Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto- 1-oxopropyl)maytansine)
Compare

Anti-EGFR-mc-MMAF ADC (ADC-039CL)
- Target: EGFR
- Linker: Mc (maleimidocaproyl)
- Drug: MMAF (Monomethyl auristatin F)
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Anti-EGFR (MAb806)-Mc-MMAF ADC (ADC-109LCT)
- Target: EGFR
- Linker: Mc (maleimidocaproyl)
- Drug: MMAF (Monomethyl auristatin F)
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Anti-EGFR (clone Bat0206)-S-3AA-MDC ADC (ADC-157CL)
- Target: EGFR
- Linker: S-3AA
- Drug: MDC (maytansinol)
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Anti-EGFR-MC-VC-PABA-MMAE ADC (ADC-038CL)
- Target: EGFR
- Linker: MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
- Drug: MMAE (Monomethyl auristatin E)
Compare

Anti-EGFR-Mal-dPEG4-NHS-DM1 ADC (ADC-107LCT)
- Target: EGFR
- Linker: Mal-dPEG4-NHS
- Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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Anti-EGFR-MC-VC-PABA-MMAE ADC (ADC-037CL)
- Target: EGFR
- Linker: MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
- Drug: MMAE (Monomethyl auristatin E)
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Anti-EGFR-EDC/NHS-methotrexate ADC (ADC-060LZY)
- Target: EGFR
- Linker: EDC/NHS
- Drug: MTX
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For Research Use Only. Not For Clinical Use.

Background

Receptor for EGF, but also for other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation. Phosphorylates MUC1 in breast cancer cells and increases the interaction of MUC1 with SRC and CTNNB1/beta-catenin. Isoform 2 may act as an antagonist of EGF action.

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Related Signaling Pathways

JAK-STAT Signaling Pathway