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EGFR & ErbB-3

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Anti-EGFR & ErbB-3 Recombinant Antibody Products

  • Anti-EGFR (J2898A)-SMCC-DM1 ADC (IMGN289) (ADC-L016)
    • Target: EGFR
    • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto- 1-oxopropyl)maytansine)
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  • Anti-EGFR-MC-VC-PABA-MMAE ADC (ADC-037CL)
    • Target: EGFR
    • Linker: MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
    • Drug: MMAE (Monomethyl auristatin E)
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  • Anti-EGFR-MC-VC-PABA-MMAE ADC (ADC-038CL)
    • Target: EGFR
    • Linker: MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
    • Drug: MMAE (Monomethyl auristatin E)
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  • Anti-EGFR-mc-MMAF ADC (ADC-039CL)
    • Target: EGFR
    • Linker: Mc (maleimidocaproyl)
    • Drug: MMAF (Monomethyl auristatin F)
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  • Anti-EGFR-vc-PAB-MODO ADC (ADC-263CL)
    • Target: epidermal growth factor receptor (EGFR)
    • Linker: VC-PAB (valine-citrulline-p-aminobenzoyloxycarbonyl)
    • Drug: MODO (monomethyldolastatin)
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  • Anti-EGFR (MAb806)-SMCC-DM1 ADC (ADC-110LCT)
    • Target: EGFR variant III
    • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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  • Anti-EGFR (clone J2898A)-SMCC-DM1 ADC (ADC-047LZY)
    • Target: EGFR
    • Linker: SMCC (N-succinimidyl-4-(N-maleimidomethyl)-cyclohexane-1-carboxylate)
    • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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  • Anti-EGFRvIII-SMCC-DM1 ADC (ADC-048LZY)
    • Target: EGFRvIII
    • Linker: SMCC (N-succinimidyl-4-(N-maleimidomethyl)-cyclohexane-1-carboxylate)
    • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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  • Anti-EGFR-MCC-Dox ADC (ADC-057LZY)
    • Target: EGFR
    • Linker: MCC (4-(N-maleimidomethyl)cyclohexane-1-carboxylate)
    • Drug: doxorubicin
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  • Anti-EGFR-EDC/NHS-Dox ADC (ADC-058LZY)
    • Target: EGFR
    • Linker: EDC/NHS(1-ethyl-3-(3-diaminopropyl)carbodiimide/N-hydroxysuccinimide)
    • Drug: doxorubicin
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  • Anti-EGFR-SMCC-methotrexate ADC (ADC-059LZY)
    • Target: EGFR
    • Linker: SMCC (N-succinimidyl-4-(N-maleimidomethyl)-cyclohexane-1-carboxylate)
    • Drug: MTX
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  • Cetuximab (Gly-015CL)
    • CAS number: 205923-56-4
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EGFR encodes a receptor tyrosine kinase that is involved in the regulation of cell growth, survival, and differentiation. It is activated by binding to its ligands, such as epidermal growth factor (EGF), and mediates downstream signaling pathways that control cellular processes like proliferation, migration, and differentiation. EGFR is critical in normal development, wound healing, and tissue repair. However, mutations or overexpression of EGFR are associated with various cancers, including non-small cell lung cancer (NSCLC), making EGFR a target for cancer therapies, including monoclonal antibodies and tyrosine kinase inhibitors.
EGFR & ErbB-3
Related Diseases
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Related Signaling Pathways
JAK-STAT Signaling Pathway JAK-STAT Signaling Pathway
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