Human Anti-EBOV GP Recombinant Antibody (clone 2G1) (CAT#: FAMAB-0154WJ)
This product is a human antibody binds all four ebolavirus GPs and presented a wide cross-reactivity to ebolavirus GPs. This antibody can be used in applications, such as ELISA, WB, Neut.
Specific Inquiry
ELISA
Figure 1 Profiles of antibody binding abilities.
Binding curves of mAb 2G1 to ebolavirus GPs or truncated EBOV GPs.
Fan, P., Chi, X., Liu, G., Zhang, G., Chen, Z., Liu, Y., Fang, T., Li, J., Banadyga, L., He, S., Yu, C., Qiu, X., & Chen, W. (2020). Potent neutralizing monoclonal antibodies against Ebola virus isolated from vaccinated donors. mAbs, 12(1), 1742457.
Neut
Figure 2 Profiles of antibody neutralizing abilities.
Neutralization of cross-reactive mAbs or Fab to HIV-EBOV/BDBV/SUDV GP-Luc.
Fan, P., Chi, X., Liu, G., Zhang, G., Chen, Z., Liu, Y., Fang, T., Li, J., Banadyga, L., He, S., Yu, C., Qiu, X., & Chen, W. (2020). Potent neutralizing monoclonal antibodies against Ebola virus isolated from vaccinated donors. mAbs, 12(1), 1742457.
IF
Figure 3 Binding of mAbs to EBOV GP displayed on the surface of BHK-T7 cells.
Images were acquired under a 4× objective on a Cytation imaging reader.
Fan, P., Chi, X., Liu, G., Zhang, G., Chen, Z., Liu, Y., Fang, T., Li, J., Banadyga, L., He, S., Yu, C., Qiu, X., & Chen, W. (2020). Potent neutralizing monoclonal antibodies against Ebola virus isolated from vaccinated donors. mAbs, 12(1), 1742457.
FC
Figure 4 Binding of mAbs to uncleaved or cleaved EBOV GP/GPΔMuc displayed on the surface of 293 T cells and analyzed using flow cytometry.
Fold change in mAb binding after thermolysin cleavage was calculated by comparing the percentage of PE-positive cells with or without thermolysin (THL) digestion.
Fan, P., Chi, X., Liu, G., Zhang, G., Chen, Z., Liu, Y., Fang, T., Li, J., Banadyga, L., He, S., Yu, C., Qiu, X., & Chen, W. (2020). Potent neutralizing monoclonal antibodies against Ebola virus isolated from vaccinated donors. mAbs, 12(1), 1742457.
Specifications
- Host Species
- Human
- Type
- Human IgG
- Specificity
- EBOV GP
- Species Reactivity
- EBOV
- Clone
- 2G1
- Applications
- ELISA, WB, Neut
- Related Disease
- EBOV infection
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Ebola virus; EBOV
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone 2G1"
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Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-298-F(E) | Recombinant Human Anti-EBOV GP Antibody Fab Fragment | WB, IHC, FuncS | Fab |
| PFBW-038 | Recombinant Mouse Anti-EBOV GP Antibody Fab Fragment (14G7) | ELISA, Neut | IgG |
| PFBL-455 | Recombinant Human Anti-EBOV GP Antibody Fab Fragment (KZ52 ) | Neut | Fab |
| HPAB-0411-FY-F(E) | Human Anti-EBOV GP Recombinant Antibody; Fab Fragment (HPAB-0411-FY-F(E)) | ELISA, Neut | Human Fab |
| HPAB-0412-FY-F(E) | Human Anti-EBOV GP Recombinant Antibody; Fab Fragment (HPAB-0412-FY-F(E)) | ELISA, Neut | Human Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-455 | Recombinant Human Anti-EBOV GP Antibody scFv Fragment (KZ52 ) | Neut | scFv |
| HPAB-592-FY-S(P) | Mouse Anti-EBOV GP Recombinant Antibody; scFv Fragment (HPAB-592-FY-S(P)) | WB, ELISA, Neut | Mouse scFv |
| HPAB-N0106-YC-S(P) | Macaque Anti-EBOV GP Recombinant Antibody; scFv Fragment (HPAB-N0106-YC-S(P)) | ELISA, FC, Neut | Macaque scFv |
| HPAB-0747YY-S(P) | Human Anti-EBOV GP Recombinant Antibody; scFv Fragment (HPAB-0747YY-S(P)) | ELISA, Neut | Humanized scFv |
| PABJ-0144-S(P) | Human Anti-EBOV GP Recombinant Antibody (clone 3T0331); scFv Fragment | ELISA, Neut | Human scFv |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-900LC | Anti-EBOV GP Recombinant Antibody (13F6) | WB | Mouse antibody |
| MRO-901LC | Anti-EBOV GP Recombinant Antibody (6D8) | ELISA | Mouse antibody |
| MRO-902LC | Anti-EBOV GP Recombinant Antibody (12B5) | ELISA | Mouse antibody |
| MRO-903LC | Anti-EBOV GP Recombinant Antibody (13C6) | WB | Mouse antibody |
| MRO-904LC | Anti-EBOV GP Recombinant Antibody (6D3) | ELISA | Mouse antibody |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-917LC | Anti-EBOV GP Recombinant Antibody (EVB100) | ELISA | Human antibody |
| MRO-918LC | Anti-EBOV GP Recombinant Antibody (EVB166) | ELISA | Human antibody |
| MRO-919LC | Anti-EBOV GP Recombinant Antibody (EVB167) | ELISA | Human antibody |
| MRO-920LC | Anti-EBOV GP Recombinant Antibody (EVB165) | ELISA | Human antibody |
| MRO-921LC | Anti-EBOV GP Recombinant Antibody (EVB114v1) | ELISA | Human antibody |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-927LC | Mouse Anti-EBOV GP Recombinant Antibody (MRO-927LC) | ELISA | Mouse IgG1, κ |
| MRO-927LC-S(P) | Mouse Anti-EBOV GP Recombinant Antibody (MRO-927LC-S(P)); scFv Fragment | ELISA | Mouse scFv |
| MRO-927LC-F(E) | Mouse Anti-EBOV GP Recombinant Antibody (MRO-927LC-F(E)); Fab Fragment | ELISA | Mouse Fab |
Epitope-Specific Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| EPAF-0983LC | Recombinant Mouse Anti-EBOV GP Antibody (133/3.16) | ELISA, FuncS | IgG1 |
| EPAF-0213CQ | Recombinant Mouse Anti-EBOV GP Antibody (226/8.1) | Neut | IgG1 |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0106-YC | Macaque Anti-EBOV GP Recombinant Antibody (HPAB-N0106-YC) | ELISA, FC, Neut | Macaque IgG |
| HPAB-1098WJ | Mouse Anti-EBOV GP Recombinant Antibody (HPAB-1098WJ) | ELISA, WB | Mouse IgG, κ |
| HPAB-0734YY | Human Anti-EBOV GP Recombinant Antibody (HPAB-0734YY) | ELISA, Neut | Human IgG1 |
| HPAB-0735YY | Human Anti-EBOV GP Recombinant Antibody (HPAB-0735YY) | ELISA, Neut | Humanized IgG1 |
| HPAB-0736YY | Human Anti-EBOV GP Recombinant Antibody (HPAB-0736YY) | ELISA, Neut | Humanized IgG1 |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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