Mouse Anti-Hba Recombinant Antibody (clone 2A1) (CAT#: FAMAB-1355CQ)
This product is a recombinant mouse antibody that recognizes Hba. The antibody was purified by affinity chromatography. It can be used in WB, ELISA.
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FuncS
Figure 1 Elicitation of inflammatory cytokines and transmigratory signals by Hb and Hb-antibody complexes.
(A-C) Effect of Hb (20 μM) and Hb plus various antibodies (≅1-2 μg equivalent) on the secretion of (A) TNF-α (*p=0.0005 versus Hb; **p=0.008 versus antibody 2A1); (B) IL-6 (*p=0.012 versus Hb; **p=0.013 versus antibody 2A1; ***p=0.001 versus medium); (C) IL-8 (*p=0.008 versus Hb; **p=0.0002 versus antibody 2A1; ***p=0.004 versus medium) from THP-1 cells. (D) Transmigration of THP-1 cells upon exposure to supernatants of HBMEC incubated with the indicated reagents (*p=0.013 versus Hb; **p=0.028 versus antibody 2A1; ***p=0.0009 versus Hb+I.C.). I.C.: Isotype control (Anti-TNP, IgMκ, 2 μg). Plots represent means of three experiments, along with standard errors. Significances were calculated by Student's t-test.
Bhatnagar, H., Kala, S., Sharma, L., Jain, S., Kim, K. S., & Pal, R. (2011). Serum and organ‐associated anti‐hemoglobin humoral autoreactivity: Association with anti‐Sm responses and inflammation. European journal of immunology, 41(2), 537-548.
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG1
- Species Reactivity
- Mouse
- Clone
- 2A1
- Applications
- WB, ELISA
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Haemoglobin
- UniProt ID
- P01942
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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