Rabbit Anti-LATS1 Polyclonal Antibody (CAT#: VS3-WK1566)
This antibody is a rabbit polyclonal antibody against human LATS1, which is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. It was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen (synthesized peptide derived from human LATS1). It can detect endogenous levels of LATS1. This product was tested for use in WB and ELISA.
Specific Inquiry
Specifications
- Immunogen
- Synthesized peptide derived from human LATS1/2
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human LATS1
- Species Reactivity
- Human, Mouse, Rat
- Applications
- WB, ELISA
- Conjugate
- Unconjugated
Product Property
- Clonality
- Polyclonal
- Purification
- Affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Aggregation
- < 5%
- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS, 0.5% BSA, 50% Glycerol
- Preservative
- 0.02% Sodium Azide
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- This antibody has been tested for use in Western Blot (1:500) and ELISA (1:10000-1/20000).
Target
- Alternative Names
- Large Tumor Suppressor Kinase 1; LATS (Large Tumor Suppressor, Drosophila) Homolog 1; Large Tumor Suppressor Homolog 1; WARTS Protein Kinase; H-Warts; WARTSLATS, Large Tumor Suppressor, Homolog 1 (Drosophila); LATS, Large Tumor Suppressor, Homolog 1; Serine/Threonine-Protein Kinase LATS1; EC 2.7.11.1; Wts
- Gene ID
- 9113
- UniProt ID
- O95835
- Long Name
- Large Tumor Suppressor Kinase 1
- Sequence Similarities
- Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.
- Cellular Localization
- Cytoplasm, Cytoskeleton
- Post Translation Modifications
- Autophosphorylated and phosphorylated during M-phase of the cell cycle.
Phosphorylated by STK3/MST2 at Ser-909 and Thr-1079, which results in its activation.
Phosphorylation at Ser-464 by NUAK1 and NUAK2 leads to decreased protein level and is required to regulate cellular senescence and cellular ploidy.
- Protein Refseq
- NP_001257448.1
- Function
- Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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