Disease related genes, Human disease related genes, Potential drug targets, Transporters
Membrane
Cell type enhanced (Late spermatids, Early spermatids, Cardiomyocytes, Spermatocytes, Oligodendrocytes)
Not detected in immune cells
Cell line enhanced (RH-30, WM-115)
Homodimer. Homodimerization requires the C-terminus cytoplasmic region. Interacts (via the C-terminus cytoplasmic tail) with TJP1. Interacts (via the C-terminus cytoplasmic tail) with ARHGEF25/GEFT (via the DH domain). Interacts (via the C-terminus cytoplasmic tail) with VAMP3 (By similarity). Interacts with KCNK2; the interaction enhances KCNK2 surface expression and is inhibited by cAMP (By similarity) (PubMed:26642364). Interacts with CAV3 (By similarity).
Developmental protein
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For Research Use Only. Not For Clinical Use.