Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets
Intracellular
Cell type enhanced (Langerhans cells, monocytes, Proximal enterocytes, granulocytes)
Immune cell enhanced (memory B-cell, naive B-cell)
Cell line enhanced (CAPAN-2, Daudi, EFO-21, HDLM-2, hTERT-HME1, U-266/70, U-266/84)
Interacts with PRSS25; interaction inhibits apoptotic suppressor activity. The BIR motifs region interacts with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2) to form a heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2). Interaction with TRAF2 is required for ubiquitination of IKBKE, degradation of NFKBIA and activation of NF-kappa-B. Interacts with RIP1, RIP2, RIP3, RIP4 and USP19.
Transferase
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For Research Use Only. Not For Clinical Use.