Rabbit Anti-BIRC3 Recombinant Antibody (clone R08-7B9) (CAT#: VS3-XY3278)

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human BIRC3

• Species Reactivity
• Human

• Clone
• R08-7B9

• Applications
• WB, IHC-P, ICC, IF, IP

• Related Disease
• Lymphoma, Mucosa-Associated Lymphoid Type; Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue

• Clonality
• Monoclonal

• Aggregation
• < 5%

• Format
• Liquid

• Buffer
• PBS (pH 7.4), 150 mM NaCl and 50% glycerol

• Preservative
• 0.02% sodium azide

• Storage
• Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• WB: 1/500-1/1000
  IHC: 1/50-1/100
  IF: 1/50-1/200
  IP: 1/20

• Alternative Names
• AIP1; API2; MIHC; CIAP2; HAIP1; HIAP1; IAP-1; MALT2; RNF49; c-IAP2

• Gene ID
• 330

• UniProt ID
• Q13489

• Long Name
• Baculoviral IAP repeat containing 3

• Cellular Localization
• Cytoplasm, Nucleus

• Post Translation Modifications
• Auto-ubiquitinated and degraded by the proteasome in apoptotic cells.

• Protein Refseq
• NP_892007.1; NP_001156.1

• Function
• Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling.

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Recommended Dilution Buffer

• MRO-0253YJ
• Reconstitution Buffer PBS

Secondary Antibody

• 2RD-A1473-YJ
• Goat Anti-Rabbit IgG-F(ab')2 Secondary antibody

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