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COMP
COMP (Cartilage Oligomeric Matrix Protein) is a Protein Coding gene. Diseases associated with COMP include Pseudoachondroplasia and Epiphyseal Dysplasia, Multiple, 1. Among its related pathways are ECM proteoglycans and PI3K-Akt signaling pathway. Gene Ontology (GO) annotations related to this gene include calcium ion binding and protease binding. An important paralog of this gene is THBS4.
Protein class
Disease related genes, Human disease related genes, Plasma proteins
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Late spermatids, Early spermatids, Glandular and luminal cells, Fibroblasts, Basal respiratory cells, Spermatocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enriched (fHDF/TERT166)
Interaction
Pentamer; disulfide-linked (PubMed:32686688). Exists in a more compact conformation in the presence of calcium and shows a more extended conformation in the absence of calcium (PubMed:19276170). Interacts with ITGB3, ITGA5 and FN1. Binding to FN1 requires the presence of divalent cations (Ca(2+), Mg(2+) or Mn(2+)). The greatest amount of binding is seen in the presence of Mn(2+) (PubMed:16051604, PubMed:12225811). Interacts with MATN1, MATN3, MATN4 and ACAN (PubMed:15075323, PubMed:17588949). Binds heparin, heparan sulfate and chondroitin sulfate. EDTA dimishes significantly its binding to ACAN and abolishes its binding to MATN3, MATN4 and chondroitin sulfate (PubMed:17588949). Interacts with collagen I, II and IX, and interaction with these collagens is dependent on the presence of zinc ions (PubMed:11084047). Interacts with ADAMTS12 (PubMed:16611630). Interacts with ITGA7 (By similarity).
Molecular function
Heparin-binding
More Types Infomation
- Rat Anti-COMP Recombinant Antibody (Clone 15A) (PABS-0006)
-
- Species Reactivity: Rat
- Type: Rat IgG
- Application: ELISA, FuncS
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- Species Reactivity: Rat
- Type: Rat Fab
- Application: ELISA, FuncS
- Mouse Anti-COMP Recombinant Antibody (clone 2G5) (MOB-1857z)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA
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- Species Reactivity: Rat
- Type: Rat scFv
- Application: ELISA, FuncS
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, FC
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA
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For Research Use Only. Not For Clinical Use.