Intracellular
Cell type enhanced (Horizontal cells, Bipolar cells, Muller glia cells, Inhibitory neurons, Excitatory neurons)
Not detected in immune cells
Cell line enhanced (AF22, HAP1, NTERA-2, REH, RH-30, SCLC-21H, SH-SY5Y)
Homotetramer, and heterotetramer with DPYSL2, DPYSL3, DPYSL4 or DPYSL5 (By similarity). Interacts with PLXNA1 (By similarity). Interacts with FLNA (via calponin-homology (CH) domain 1 and filamin repeat 24); the interaction alters FLNA ternary structure and thus promotes FLNA dissociation from F-actin (PubMed:25358863).
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For Research Use Only. Not For Clinical Use.