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CerS5
CERS5 robustly synthesizes C16-ceramide, which is often considered to be an important pro-apoptotic ceramide. De novo ceramide synthesis is an essential trigger for Bax activation in hypoxia/reoxygenation. Following hypoxia/reoxygenation, CERS5 expression is elevated. Upon knocking down acid sphingomyelinase and CERS5 in NTERA-2cells, Bax localization to mitochondria was reduced, indicating the importance of CERS5 activity in the apoptosis pathway.
Protein class
Enzymes, Metabolic proteins
Predicted location
Membrane
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Molecular function
Transferase
More Types Infomation
- Recombinant Mouse Anti-Trh4 Soluble TCR (clone LnB5) (scTCR-026CQ-S(P))
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- Species Reactivity: Mouse
- Epitope: MCLRMTAVM
- MHC: H-2Db
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- Species Reactivity: Mouse
- Epitope: MCLRMTAVM
- MHC: H-2Db
- Recombinant Mouse Anti-Trh4 Soluble TCR (LnB5) (C-Cys) (VS-0622-YF2734)
-
- Species Reactivity: Mouse
- Epitope: MCLRMTAVM
- MHC: H-2Db
- Recombinant Mouse Anti-Trh4 Soluble TCR (LnB5) (KIH) (VS-0622-YF5442)
-
- Species Reactivity: Mouse
- Epitope: MCLRMTAVM
- MHC: H-2Db
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For Research Use Only. Not For Clinical Use.