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KLHL25
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E.
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Horizontal cells)
Immune cell specificity
Immune cell enhanced (non-classical monocyte)
Cell line specificity
Low cell line specificity
Interaction
Component of the BCR(KLHL25) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL25 and RBX1. Interacts with EIF4EBP1 (when hypophosphorylated).
More Types Infomation
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- Species Reactivity: Human
- Application: WB
- Chicken Anti-KLHL25 Polyclonal IgY (BRD-0778MZ)
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- Species Reactivity: Human
- Type: Chicken antibody
- Application: ICC, IF, WB
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, ELISA
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: WB, IHC, ICC, FC, ELISA
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For Research Use Only. Not For Clinical Use.