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LRP8
Low-density lipoprotein receptor-related protein 8 (LRP8), also known as apolipoprotein E receptor 2 (ApoER2), is a protein encoded by the LRP8 gene in the human body. ApoER2 is a cell surface receptor and part of the low density lipoprotein receptor family. These receptors play a role in signal transduction and endocytosis of specific ligands. Through its interaction with one of its ligands, reelin, ApoER2 plays an important role in embryonic neuron migration and long-term postpartum enhancement. Another LDL family receptor, VLDLR, also interacts with reelin, and these two receptors jointly affect brain development and function. The decreased expression of ApoER2 is related to certain neurological diseases.
Protein class
Disease related genes
Predicted location
Intracellular, Membrane, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Inhibitory neurons, Granulosa cells, Bipolar cells, Microglial cells, Excitatory neurons, Astrocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Homooligomer (PubMed:30873003). Interacts with VLDLR (PubMed:30873003). Reelin associates with two or more receptor molecules (PubMed:20223215). Interacts with DAB1 and JNK-interacting proteins. Interacts with SNX17 (By similarity). Interacts with PCSK9. Interacts with MDK; this interaction is calcium dependent (By similarity). Interacts with CLU (PubMed:24381170). (Microbial infection) Interacts with Semliki Forest virus E2-E1 heterodimer; this interaction mediates viral entry to host cell.
Molecular function
Receptor
More Types Infomation
- Rabbit Anti-LRP8 Polyclonal Antibody (MRO-1657-CN) (MRO-1657-CN)
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- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, IP
- Recombinant Mouse Anti-Human LRP8 Antibody (MOB-0660MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: FC
-
- Species Reactivity: Human, Rat, Hamster
- Type: Rabbit IgG
- Application: WB, IP
- Mouse Anti-LRP8 Recombinant Antibody; scFv Fragment (HPAB-623-FY-S(P)) (HPAB-623-FY-S(P))
-
- Species Reactivity: Human, Mouse
- Type: Mouse scFv
- Application: IHC
- Mouse Anti-LRP8 Recombinant Antibody; scFv Fragment (HPAB-622-FY-S(P)) (HPAB-622-FY-S(P))
-
- Species Reactivity: Human, Mouse
- Type: Mouse scFv
- Application: FC, IHC
- Human Anti-LRP8 Recombinant Antibody; scFv Fragment (HPAB-621-FY-S(P)) (HPAB-621-FY-S(P))
-
- Species Reactivity: Human, Mouse, Cynomolgus monkey
- Type: Human scFv
- Application: FC, ELISA
- Mouse Anti-LRP8 Recombinant Antibody (HPAB-623-FY) (HPAB-623-FY)
-
- Species Reactivity: Human, Mouse
- Type: Mouse IgG
- Application: IHC
- Mouse Anti-LRP8 Recombinant Antibody (HPAB-622-FY) (HPAB-622-FY)
-
- Species Reactivity: Human, Mouse
- Type: Mouse IgG
- Application: FC, ELISA
- Human Anti-LRP8 Recombinant Antibody (HPAB-621-FY) (HPAB-621-FY)
-
- Species Reactivity: Human, Mouse, Cynomolgus monkey
- Type: Human IgG1, κ
- Application: FC, ELISA
- Mouse Anti-LRP8 Recombinant Antibody (HPAB-620-FY) (HPAB-620-FY)
-
- Species Reactivity: Human, Mouse
- Type: Mouse IgG
- Application: FC
- Mouse Anti-LRP8 Recombinant Antibody; Fab Fragment (HPAB-623-FY-F(E)) (HPAB-623-FY-F(E))
-
- Species Reactivity: Human, Mouse
- Type: Mouse Fab
- Application: IHC
- Mouse Anti-LRP8 Recombinant Antibody; Fab Fragment (HPAB-622-FY-F(E)) (HPAB-622-FY-F(E))
-
- Species Reactivity: Human, Mouse
- Type: Mouse Fab
- Application: FC, IHC
- Human Anti-LRP8 Recombinant Antibody; Fab Fragment (HPAB-621-FY-F(E)) (HPAB-621-FY-F(E))
-
- Species Reactivity: Human, Mouse, Cynomolgus monkey
- Type: Human Fab
- Application: FC, ELISA
- Mouse Anti-LRP8 Recombinant Antibody; Fab Fragment (HPAB-620-FY-F(E)) (HPAB-620-FY-F(E))
-
- Species Reactivity: Human, Mouse
- Type: Mouse Fab
- Application: FC
- Mouse Anti-LRP8 Recombinant Antibody; scFv Fragment (HPAB-620-FY-S(P)) (HPAB-620-FY-S(P))
-
- Species Reactivity: Human, Mouse
- Type: Mouse scFv
- Application: FC
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For Research Use Only. Not For Clinical Use.