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MARS
This gene encodes a member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. The encoded protein is a component of the multi-tRNA synthetase complex and catalyzes the ligation of methionine to tRNA molecules. [provided by RefSeq, Jan 2011]
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Syncytiotrophoblasts, Cytotrophoblasts, Extravillous trophoblasts, Hofbauer cells, Cardiomyocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (RH-30)
Interaction
Monomer (PubMed:11714285). Part of a multisubunit complex that groups tRNA ligases for Arg (RARS1), Asp (DARS1), Gln (QARS1), Ile (IARS1), Leu (LARS1), Lys (KARS1), Met (MARS1) the bifunctional ligase for Glu and Pro (EPRS1) and the auxiliary subunits AIMP1/p43, AIMP2/p38 and EEF1E1/p18 (PubMed:19131329, PubMed:19289464, Ref.24, PubMed:26472928). Forms a linear complex that contains MARS1, EEF1E1, EPRS1 and AIMP2 that is at the core of the multisubunit complex (PubMed:26472928).
Molecular function
Aminoacyl-tRNA synthetase, Ligase, RNA-binding, tRNA-binding
More Types Infomation
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, ICC, FC
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- Species Reactivity: Human
- Type: Human IgG1, κ
- Application: ELISA, IP
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For Research Use Only. Not For Clinical Use.