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PCDHB6

This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. Unlike the alpha and gamma clusters, the transcripts from these genes do not share common 3 exons. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell neural connections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Predicted location

Membrane

Single cell type specificity

Cell type enriched (Spermatocytes)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (EFO-21, SH-SY5Y, T-47d, U-2197, WM-115)

Interaction

Forms homodimers in trans (molecules expressed by two different cells). Forms promiscuous heterodimers in cis (at the plasma membrane of the same cell) with other protocadherins.

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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