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PDGFRB
Enables platelet-derived growth factor-activated receptor activity and signaling receptor binding activity. Involved in several processes, including positive regulation of intracellular signal transduction; protein phosphorylation; and vasculature development. Acts upstream of or within several processes, including animal organ development; response to ceramide; and ruffle assembly. Located in cell surface; cytoplasm; and ruffle. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; nervous system; and sensory organ. Used to study basal ganglia calcification; infantile myofibromatosis; myeloproliferative neoplasm; and severe nonproliferative diabetic retinopathy. Human ortholog(s) of this gene implicated in basal ganglia calcification; glioblastoma; infantile myofibromatosis; myeloproliferative neoplasm (multiple); and renal cell carcinoma. Orthologous to human PDGFRB (platelet derived growth factor receptor beta).
Protein class
Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, RAS pathway related proteins
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enriched (Sertoli cells)
Immune cell specificity
Immune cell enhanced (non-classical monocyte)
Cell line specificity
Group enriched (ASC diff, ASC TERT1)
Interaction
Interacts with homodimeric PDGFB and PDGFD, and with heterodimers formed by PDGFA and PDGFB. May also interact with homodimeric PDGFC. Monomer in the absence of bound ligand. Interaction with homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFD, leads to receptor dimerization, where both PDGFRA homodimers and heterodimers with PDGFRB are observed. Interacts with SH2B2/APS. Interacts directly (tyrosine phosphorylated) with SHB. Interacts (tyrosine phosphorylated) with PIK3R1 and RASA1. Interacts (tyrosine phosphorylated) with CBL. Interacts (tyrosine phosphorylated) with SRC and SRC family kinases. Interacts (tyrosine phosphorylated) with PIK3C2B, maybe indirectly. Interacts (tyrosine phosphorylated) with SHC1, GRB7, GRB10 and NCK1. Interaction with GRB2 is mediated by SHC1. Interacts (via C-terminus) with SLC9A3R1.
Molecular function
Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase
More Types Infomation
- Human Anti-Pdgfrb Antibody Fab Fragment (1B3) (MOB-141CQ)
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- Species Reactivity: Mouse
- Type: Human Fab
- Application: FC, WB, Neut
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC, IP
-
- Species Reactivity: Human
- Type: Mouse antibody
- Application: FC
-
- Species Reactivity: Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF
- Rabbit Anti-PDGFRB Polyclonal Antibody (MRO-2112-CN) (MRO-2112-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, IF, WB
-
- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB
- Recombinant Rat Anti-Pdgfrb Antibody (APB5) (NEUT-1850CQ)
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- Species Reactivity: Mouse
- Type: IgG2a, κ
- Application: FC, FuncS, Neut
- Human Anti-PDGFRB Recombinant Antibody (clone PFH2); scFv Fragment (HPAB-N0227-YC-S(P))
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- Derivation: Phage display library
- Species Reactivity: Human, Mouse, Rat
- Type: Human scFv
- Application: Block
- Human Anti-PDGFRB Recombinant Antibody (clone 1B3); Fab Fragment (HPAB-0281CQ-F(E))
-
- Species Reactivity: Mouse
- Type: Human Fab
- Application: ELISA, FC, WB, Neut
- Human Anti-PDGFRB Recombinant Antibody (clone HuM4TS.22); Fab Fragment (HPAB-S0108-YC-F(E))
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA, Neut
- Human Anti-PDGFRB Recombinant Antibody (clone 1B3); scFv Fragment (HPAB-0281CQ-S(P))
-
- Species Reactivity: Mouse
- Type: Human scFv
- Application: ELISA, FC, WB, Neut
- Human Anti-PDGFRB Recombinant Antibody; scFv Fragment (HPAB-1113-CN-S(P)) (HPAB-1113-CN-S(P))
-
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA
-
- Species Reactivity: Mouse, Rat
- Type: Rabbit IgG
- Application: WB, ICC, IF
- Mouse Anti-PDGFRB Recombinant Antibody (clone muM4TS.22); Fab Fragment (HPAB-S0107-YC-F(E))
-
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, Neut
- Human Anti-PDGFRB Recombinant Antibody; Fab Fragment (HPAB-1113-CN-F(E)) (HPAB-1113-CN-F(E))
-
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA
- Human Anti-PDGFRB Recombinant Antibody; scFv Fragment (HPAB-1112-CN-S(P)) (HPAB-1112-CN-S(P))
-
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA
-
- Derivation: Mouse
- Species Reactivity: Human, Mouse
- Type: Mouse IgG1
- Application: WB, IHC, ICC, FC, ELISA
- Human Anti-PDGFRB Recombinant Antibody (clone HuM4TS.11); Fab Fragment (HPAB-S0106-YC-F(E))
-
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA, Neut
- Human Anti-PDGFRB Recombinant Antibody; Fab Fragment (HPAB-1112-CN-F(E)) (HPAB-1112-CN-F(E))
-
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA
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