Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Transporters, Voltage-gated ion channels
Membrane
Cell type enhanced (Oligodendrocytes, Oligodendrocyte precursor cells, Inhibitory neurons, Excitatory neurons, Microglial cells)
Immune cell enhanced (basophil)
Cell line enhanced (BJ, BJ hTERT+, fHDF/TERT166)
Homotetramer (PubMed:20881056, 27768895, 27991905, 28092368, 29899465). Heterotetramer with PKD1, giving rise to a complex formed by one PKD1 chain and three PKD2 chains (PubMed:20881056, 19556541, 27214281, 30093605). Interaction with PKD1 is required for ciliary localization (By similarity) Isoform 1 interacts with PKD1 while isoform 3 does not (By similarity). Interacts with PKD1L1. Interacts with CD2AP (PubMed:10913159). Interacts with HAX1 (PubMed:10760273). Interacts with NEK8 (By similarity). Part of a complex containing AKAP5, ADCY5, ADCY6 and PDE4C (By similarity). Interacts (via C-terminus) with TRPV4 (via C-terminus) (PubMed:18695040). Interacts (via C-terminal acidic region) with PACS1 and PACS2; these interactions retain the protein in the endoplasmic reticulum and prevent trafficking to the cell membrane (PubMed:15692563). Interacts with TMEM33 (By similarity).
Calcium channel, Ion channel, Potassium channel, Voltage-gated channel
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For Research Use Only. Not For Clinical Use.