Disease related genes, Human disease related genes, Metabolic proteins
Intracellular
Cell type enhanced (Oligodendrocytes, Astrocytes, Oligodendrocyte precursor cells, Late spermatids, Excitatory neurons, Inhibitory neurons)
Group enriched (memory CD8 T-cell, gdT-cell, MAIT T-cell, naive CD8 T-cell, T-reg, NK-cell, memory CD4 T-cell)
Cell line enhanced (HaCaT, HDLM-2, RT4)
PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules (By similarity). Interacts with TOMM22 (By similarity). Interacts with IER5 (via N- and C-terminal regions) (PubMed:25816751, 26496226).
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For Research Use Only. Not For Clinical Use.