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RSPO2
This gene encodes a member of the R-spondin family of proteins. These proteins are secreted ligands of leucine-rich repeat containing G protein-coupled receptors that enhance Wnt signaling through the inhibition of ubiquitin E3 ligases. A chromosomal translocation including this locus that results in the formation of a gene fusion has been identified in multiple human cancers. Alternative splicing results in multiple transcript variants.
Protein class
Cancer-related genes, Disease related genes, Human disease related genes
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Group enriched (Inhibitory neurons, Excitatory neurons)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (HEK93, U-266/70)
Interaction
Interacts with WNT1 (By similarity). Binds heparin (By similarity). Interacts with LGR4, LGR5 and LGR6 (PubMed:21909076, PubMed:21727895, PubMed:22615920, PubMed:29769720). Interacts with E3 ubiquitin ligases RNF43 and ZNRF3 (PubMed:29769720).
Molecular function
Developmental protein, Heparin-binding
More Types Infomation
- Recombinant Rat Anti-RSPO2 Antibody (CBL669) (NEUT-1923CQ)
-
- Species Reactivity: Human
- Type: IgG1
- Application: Neut
-
- Derivation: Mouse hybridoma cell lines
- Species Reactivity: Mouse, Cynomolgus
- Type: Mouse scFv
- Application: WB, ELISA, Neut, FC, IHC, IP
-
- Derivation: Mouse hybridoma cell lines
- Species Reactivity: Mouse, Cynomolgus
- Type: Mouse IgG
- Application: WB, ELISA, Neut, FC, IHC, IP
- Mouse Anti-RSPO2 Recombinant Antibody; Fab Fragment (TAB-349CT-F(E)) (TAB-349CT-F(E))
-
- Derivation: Mouse hybridoma cell lines
- Species Reactivity: Mouse, Cynomolgus
- Type: Mouse Fab
- Application: WB, ELISA, Neut, FC, IHC, IP
- Anti-Human RSPO2 Recombinant Antibody Fab Fragment (130M27) (TAB-0230CL-F(E))
-
- Application: ELISA, Inhib, Block, FuncS, In vivo
-
- Derivation: Mouse hybridoma cell lines
- Species Reactivity: Mouse, Cynomolgus
- Type: Mouse scFv
- Application: WB, ELISA, Neut, FC, IHC, IP
-
- Derivation: Mouse hybridoma cell lines
- Species Reactivity: Mouse, Cynomolgus
- Type: Mouse IgG
- Application: WB, ELISA, Neut, FC, IHC, IP
- Mouse Anti-RSPO2 Recombinant Antibody; Fab Fragment (TAB-348CT-F(E)) (TAB-348CT-F(E))
-
- Derivation: Mouse hybridoma cell lines
- Species Reactivity: Mouse, Cynomolgus
- Type: Mouse Fab
- Application: WB, ELISA, Neut, FC, IHC, IP
- Anti-Human RSPO2 Recombinant Antibody Fab Fragment (130M26) (TAB-0229CL-F(E))
-
- Application: ELISA, Inhib, Block, FuncS, In vivo
-
- Derivation: Mouse hybridoma cell lines
- Species Reactivity: Mouse, Cynomolgus
- Type: Mouse scFv
- Application: WB, ELISA, Neut, FC, IHC, IP
-
- Derivation: Mouse hybridoma cell lines
- Species Reactivity: Mouse, Cynomolgus
- Type: Mouse IgG
- Application: WB, ELISA, Neut, FC, IHC, IP
- Mouse Anti-RSPO2 Recombinant Antibody; Fab Fragment (TAB-347CT-F(E)) (TAB-347CT-F(E))
-
- Derivation: Mouse hybridoma cell lines
- Species Reactivity: Mouse, Cynomolgus
- Type: Mouse Fab
- Application: WB, ELISA, Neut, FC, IHC, IP
- Anti-Human RSPO2 Recombinant Antibody Fab Fragment (130M25) (TAB-0228CL-F(E))
-
- Application: ELISA, Inhib, Block, FuncS, In vivo
-
- Derivation: Mouse hybridoma cell lines
- Species Reactivity: Mouse, Cynomolgus
- Type: Mouse scFv
- Application: WB, ELISA, Neut, FC, IHC, IP
-
- Derivation: Mouse hybridoma cell lines
- Species Reactivity: Mouse, Cynomolgus
- Type: Mouse IgG
- Application: WB, ELISA, Neut, FC, IHC, IP
- Mouse Anti-RSPO2 Recombinant Antibody; Fab Fragment (TAB-346CT-F(E)) (TAB-346CT-F(E))
-
- Derivation: Mouse hybridoma cell lines
- Species Reactivity: Mouse, Cynomolgus
- Type: Mouse Fab
- Application: WB, ELISA, Neut, FC, IHC, IP
- Anti-Human RSPO2 Recombinant Antibody Fab Fragment (130M24) (TAB-0227CL-F(E))
-
- Application: ELISA, Inhib, Block, FuncS, In vivo
- Mouse Anti-RSPO2 Recombinant Antibody (VS-0224-XY106) (VS-0224-XY106)
-
- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: WB, IHC
- Anti-Human RSPO2 Recombinant Antibody Fab Fragment (130M23) (TAB-0226CL-F(E))
-
- Application: ELISA, Inhib, Block, FuncS, In vivo
- Human Anti-RSPO2 Recombinant Antibody (HPAB-0307-WJ) (HPAB-0307-WJ)
-
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized IgG
- Application: ELISA, FC, Block, Inhib, FuncS
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For Research Use Only. Not For Clinical Use.