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THBS2
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties.
Protein class
Cancer-related genes, Disease related genes, Plasma proteins
Predicted location
Secreted
Single cell type specificity
Group enriched (Fibroblasts, Basal keratinocytes, Endometrial stromal cells, Langerhans cells, Melanocytes, Oligodendrocytes, Suprabasal keratinocytes, Oligodendrocyte precursor cells, Smooth muscle cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (ASC diff, ASC TERT1, BJ hTERT+, BJ hTERT+ SV40 Large T+, BJ hTERT+ SV40 Large T+ RasG12V, HSkMC, hTEC/SVTERT24-B, U-2197)
Interaction
Homotrimer; disulfide-linked. Interacts (via the TSP type I repeats) with CD36; the interaction conveys an antiangiogenic effect. Interacts (via the TSP type I repeats) with HRG; the interaction blocks the antiangiogenic effect of THBS2 with CD36 (By similarity). Can bind to fibrinogen, fibronectin, laminin and type V collagen.
Molecular function
Heparin-binding
More Types Infomation
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, ELISA, IF, IP
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For Research Use Only. Not For Clinical Use.