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UPB1
This gene encodes a protein that belongs to the CN hydrolase family. Beta-ureidopropionase catalyzes the last step in the pyrimidine degradation pathway. The pyrimidine bases uracil and thymine are degraded via the consecutive action of dihydropyrimidine dehydrogenase (DHPDH), dihydropyrimidinase (DHP) and beta-ureidopropionase (UP) to beta-alanine and beta-aminoisobutyric acid, respectively. UP deficiencies are associated with N-carbamyl-beta-amino aciduria and may lead to abnormalities in neurological activity.
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets
Predicted location
Intracellular
Single cell type specificity
Group enriched (Hepatocytes, Proximal tubular cells)
Immune cell specificity
Group enriched (neutrophil, basophil)
Cell line specificity
Cell line enriched (CACO-2)
Interaction
Homodimer, homotetramer, homooctamer; can also form higher homooligomers.
Molecular function
Hydrolase
More Types Infomation
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC-P, IP
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- Species Reactivity: Human
- Application: ELISA, WB
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For Research Use Only. Not For Clinical Use.