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VLDLR
Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation (By similarity).
Protein class
Disease related genes, Human disease related genes
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Cone photoreceptor cells, Cardiomyocytes, Oligodendrocytes)
Immune cell specificity
Immune cell enriched (eosinophil)
Cell line specificity
Cell line enhanced (BEWO, JURKAT, THP-1)
Interaction
Homooligomer (PubMed:30873003). Binds to the extracellular matrix protein Reelin/RELN (PubMed:30873003). Interacts with LRP8 (PubMed:30873003). Interacts with LDLRAP1 (By similarity). Interacts with SNX17 (By similarity). Interacts with DAB1. Interacts with PCSK9. Interacts with PAFAH1B3 and PAFAH1B2, the catalytic complex of (PAF-AH (I)) heterotetrameric enzyme; these interactions may modulate the Reelin pathway (PubMed:17330141). Interacts with STX5; this interaction mediates VLDLR translocation from the endoplasmic reticulum to the plasma membrane (PubMed:23701949). Interacts with CLU (PubMed:24381170). (Microbial infection) Interacts with protein VP1 of the minor-group human rhinoviruses (HRVs) through the second and third LDL-receptor class A domains. (Microbial infection) Interacts with Semliki Forest virus E2-E1 heterodimer; this interaction mediates viral entry to host cell.
Molecular function
Receptor
More Types Infomation
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, IP, IF, ELISA
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- Species Reactivity: Human
- Application: ELISA, WB
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA
- Mouse Anti-VLDLR Recombinant Antibody (clone B046M) (NEUT-2272CQ)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: Block, ELISA
- Mouse Anti-VLDLR Recombinant Antibody (clone 1H5) (NEUT-2271CQ)
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- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: Block, ELISA, WB
- Mouse Anti-VLDLR Recombinant Antibody (clone 1H10) (NEUT-2270CQ)
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- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: Block, ELISA, WB
- Chicken Anti-VLDL Polyclonal IgY (BRD-0625MZ)
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- Species Reactivity: Human
- Type: Chicken antibody
- Application: Indirect ELISA, WB
- Chicken Anti-VLDLR Polyclonal IgY (BRD-0971MZ)
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- Species Reactivity: Human
- Type: Chicken antibody
- Application: ELISA, WB
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For Research Use Only. Not For Clinical Use.