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FST
Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin.
Protein class
Cancer-related genes, Candidate cardiovascular disease genes, Plasma proteins
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Cell type enriched (Granulosa cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (BJ hTERT+, HaCaT, HBEC3-KT, HMC-1, PC-3)
Interaction
Monomer. Isoform 2/FS-288 interacts with GDF11 (PubMed:28257634).
More Types Infomation
Related Signaling Pathways
TGF-β Signaling Pathway
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB
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- Species Reactivity: Human
- Application: ELISA, WB
- Mouse Anti-FST Recombinant Antibody (clone 13A7) (MOB-2802z)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA, IHC
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For Research Use Only. Not For Clinical Use.