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LGALS3

Engineered Antibody
This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides.
Protein class

Cancer-related genes, Plasma proteins

Predicted location

Intracellular, Secreted (different isoforms)

Single cell type specificity

Cell type enhanced (Proximal enterocytes, Distal enterocytes, Paneth cells)

Immune cell specificity

Group enriched (classical monocyte, intermediate monocyte, non-classical monocyte, myeloid DC, T-reg)

Cell line specificity

Cell line enhanced (ASC TERT1, CAPAN-2, OE19, SK-MEL-30)

Interaction

Probably forms homo- or heterodimers. Interacts with DMBT1 (By similarity). Interacts with CD6 and ALCAM (PubMed:24945728). Forms a complex with the ITGA3, ITGB1 and CSPG4. Interacts with LGALS3BP, LYPD3, CYHR1 and UACA. Interacts with TRIM16; this interaction mediates autophagy of damage endomembranes. Interacts with cargo receptor TMED10; the interaction mediates the translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and thereby secretion (PubMed:32272059).

Molecular function

IgE-binding protein

More Types Infomation

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