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MAP3K1
The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus.
Protein class
Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Oligodendrocyte precursor cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (SH-SY5Y, THP-1)
Interaction
Binds both upstream activators and downstream substrates in multimolecular complexes through its N-terminus (PubMed:9808624). Oligomerizes after binding MAP2K4 or TRAF2 (PubMed:9808624). Interacts with AXIN1 (PubMed:12223491, PubMed:15262978). Interacts (via the kinase catalytic domain) with STK38 (PubMed:17906693). Interacts with GRIPAP1 (PubMed:17761173).
Molecular function
Kinase, Serine/threonine-protein kinase, Transferase
More Types Infomation
Related Diseases
Endometrial Cancer
Throid Cancer
- Recombinant Mouse Anti-Human MAP3K1 Antibody (MOB-1463MZ)
-
- Species Reactivity: Human
- Type: Mouse antibody
- Application: FC, WB
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, IF, IP
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For Research Use Only. Not For Clinical Use.