Disease related genes, Human disease related genes, Transcription factors
Intracellular
Cell type enhanced (monocytes)
Low immune cell specificity
Low cell line specificity
Homodimer. The RFX heterotetrameric complex consists of 2 molecules of RFX5 and one each of RFXAP and RFX-B/RFXANK; with each subunit representing a separate complementation group. Interacts (via PxLPxI/L motif) with RFXANK (via ankyrin repeats); the interaction is direct. RFX forms cooperative DNA binding complexes with X2BP and CBF/NF-Y. RFX associates with CIITA to form an active transcriptional complex.
Activator, DNA-binding
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For Research Use Only. Not For Clinical Use.