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SIRT6
This gene encodes a member of the sirtuin family of NAD-dependent enzymes that are implicated in cellular stress resistance, genomic stability, aging and energy homeostasis. The encoded protein is localized to the nucleus, exhibits ADP-ribosyl transferase and histone deacetylase activities, and plays a role in DNA repair, maintenance of telomeric chromatin, inflammation, lipid and glucose metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]
Protein class
Enzymes, Metabolic proteins
Predicted location
Intracellular
Single cell type specificity
Group enriched (Distal enterocytes, Paneth cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Homodimer; binds to nucleosomes and DNA ends as a homodimer (PubMed:31995034, PubMed:32538779). Interacts with RELA; interferes with RELA binding to target DNA (PubMed:19135889). Interacts with SMARCA5; promoting recruitment of SMARCA5/SNF2H to double-strand breaks (DSBs) sites (PubMed:23911928). Interacts with the mTORC2 complex; preventing the ability of SIRT6 to deacetylate FOXO1. Interacts with the CLOCK-BMAL1 complex; recruited by the CLOCK-BMAL1 complex to regulate expression of clock-controlled genes. Interacts with CSNK2A2; preventing CSNK2A2 localization to the nucleus (By similarity).
Molecular function
Transferase
More Types Infomation
- Rabbit Anti-SIRT6 Polyclonal Antibody (MRO-2190-CN) (MRO-2190-CN)
-
- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, IHC, FC
-
- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IF, FC
-
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC-Fr, IHC-P, ICC, IF, IP
- Rabbit Anti-SIRT6 Recombinant Antibody (VS3-WK1059) (VS3-WK1059)
-
- Derivation: Rabbit
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, ICC, IF, FC
-
- Species Reactivity: Human, Mouse, Rat, Monkey
- Type: Mouse IgG
- Application: WB, ICC
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB
- Chicken Anti-SIRT6 Polyclonal IgY (BRD-0793MZ)
-
- Species Reactivity: Human, Mouse, Rat
- Type: Chicken antibody
- Application: WB
-
- Derivation: Mouse
- Species Reactivity: Human, Mouse, Rat, Monkey
- Type: Mouse IgG1
- Application: WB, IF, IP
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For Research Use Only. Not For Clinical Use.