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TAPBPL
Tapasin, or TAPBP (MIM 601962), is a member of the variable-constant Ig superfamily that links major histocompatibility complex (MHC) class I molecules to the transporter associated with antigen processing (TAP; see MIM 170260) in the endoplasmic reticulum (ER). The TAPBP gene is located near the MHC complex on chromosome 6p21.3. TAPBPL is a member of the Ig superfamily that is localized on chromosome 12p13.3, a region somewhat paralogous to the MHC.[supplied by OMIM, Mar 2008]
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Plasma cells, Proximal enterocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (CAPAN-2, HDLM-2, Karpas-707, RPMI-8226)
Interaction
Interacts with peptide-free HLA-A*02-B2M complexes or those loaded with low affinity peptides, likely facilitating peptide exchange onto higher affinity peptides.
More Types Infomation
-
- Class: Class I
- Antigen: TAPBPL
- Antigen Species: Human
- Peptide: GTVRTAVEF
- Conjugate: PE
- Recombinant Mouse Anti-Human TAPBPL Antibody (MOB-1540MZ)
-
- Species Reactivity: Human
- Type: Mouse antibody
- Application: WB
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For Research Use Only. Not For Clinical Use.