Recombinant monoclonal antibody specifically binds to clostridium difficile toxin A, expressed in Chinese Hamster Ovary cells(CHO).
Figure 1 Neutralization of in vivo toxicity in mice.
Mice were treated with 100 to 250 μg either of an irrelevant HuMAb or of 1B11, CDA1,or 3H2 24 h prior to intraperitoneal administration of 100 ng of toxin A. Animals were observed for up to 72 h, and the percentages of survivinganimals were plotted. The number of animals tested in each group is shown above the respective column in the bar graph. NS, not signiﬁcant.
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