Anti-C. difficile toxin A Therapeutic Antibody (1B11) (CAT#: MRO-150CT)

Recombinant monoclonal antibody specifically binds to clostridium difficile toxin A, expressed in Chinese Hamster Ovary cells(CHO).

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Neut

Figure 1 Neutralization of in vivo toxicity in mice.

Mice were treated with 100 to 250 μg either of an irrelevant HuMAb or of 1B11, CDA1,or 3H2 24 h prior to intraperitoneal administration of 100 ng of toxin A. Animals were observed for up to 72 h, and the percentages of survivinganimals were plotted. The number of animals tested in each group is shown above the respective column in the bar graph. NS, not significant.

Babcock, G. J., Broering, T. J., Hernandez, H. J., Mandell, R. B., Donahue, K., Boatright, N., ... & Ambrosino, D. M. (2006). Human monoclonal antibodies directed against toxins A and B prevent Clostridium difficile-induced mortality in hamsters. Infection and immunity, 74(11), 6339-6347.


Specifications

  • Host Species
  • Human
  • Type
  • Human antibody
  • Species Reactivity
  • C. difficile
  • Clone
  • 1B11
  • Applications
  • Neut
  • Related Disease
  • Gastrointestinal disease

Applications

  • Application Notes
  • This antibody has been reported for use in Neutralization.

Target

  • Alternative Names
  • Clostridium difficile toxin A; TcdA; Clostridium difficile; C. difficile

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

See other products for "TcdA"

* Abbreviations
3D IHC3D Immunohistochemistry
ActivActivation
AgonistAgonist
ApopApoptosis
BABioassay
BIBioimaging
BlockBlocking
Cell ScreeningCell Screening
SeparationCell Separation
ChIPChromatin Immunoprecipitation
CMCDComplement Mediated Cell Depletion
CostimCostimulation
CytCytotoxicity
DepletionDepletion
DBDot Blot
EMElectron Microscopy
ELISAEnzyme-linked Immunosorbent Assay
ELISPOTEnzyme-linked Immunosorbent Spot
FCFlow Cytometry
FuncSFunctional Assay
GSGel Super Shift Assay
HAHemagglutination
IAImmunoassay
IBImmunoblotting
ICCImmunocytochemistry
IDImmunodiffusion
IFImmunofluorescence
IHCImmunohistochemistry
IHC-FrImmunohistochemistry-Frozen
IHC-PImmunohistochemistry-Paraffin
REImmunohistology - Resin Sections
IPImmunoprecipitation
IRMAImmunoradiometric Assay
SHIn situ hybridization
InhibInhibition
ICFCIntracellular Staining for Flow Cytometry
KO/KD-WBKnockout/Knockdown target confirmation by Western Blot
Live cell imagingLive cell imaging
CyTOF®Mass Cytometry
MeDIPMethylated DNA Immunoprecipitation
MultiplexMultiplex bead-based assay
NeutNeutralization
PPProtein Purification
PGProteogenomics
RIRadial Immunodiffusion
RIARadioimmunoassay
StimStimulation
SPRSurface Plasmon Resonance
TCTissue Culture
TBTurbidimetry
WBWestern Blot

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