Recombinant Human Antibody (10-1074) is capable of binding to HIV env, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-HIV env mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-HIV env proteins mAb and CL of human light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. This antibody exhibits unusual potent neutralization, including broad reactivity against newly transmitted viruses.
Figure 1 Antibody binding at the surface of cells infected with two HIV-1 reference strains.
CEM-NKR cells infected with HIV-1 (NLAD8) were incubated with 15 μg/ml of anti-Env monoclonal antibodies. The levels of antibody bound on infected (Gag-high) and bystander (Gag-low and Gag-negative) cells were then evaluated by flow cytometry.
Bruel, T., Guivel-Benhassine, F., Lorin, V., Lortat-Jacob, H., Baleux, F., Bourdic, K., ... & Schwartz, O. (2017). Lack of ADCC breadth of human nonneutralizing anti-HIV-1 antibodies. Journal of virology, 91(8), e02440-16.
Figure 2 Delayed viral rebound with 3BNC117 and 10-1074 con\mbination therapy during ATI.
Red and blue triangles indicate 3BNC117 and 10-1074 infusions, respectively. Serum antibody concentrations were determined by TZM-bl assay.
Mendoza, P., Gruell, H., Nogueira, L., Pai, J. A., Butler, A. L., Millard, K., ... & Cohen, Y. Z. (2018). Combination therapy with anti-HIV-1 antibodies maintains viral suppression. Nature, 561(7724), 479-484.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
MOB-323 | Recombinant Anti-HIV Env Antibody | ELISA, WB, IF, FuncS | IgG |
MHH-323 | Recombinant Human Anti-HIV Env Antibody | ELISA, WB, Dot, FuncS | IgG |
PABL-509 | Human Anti-HIV Env Recombinant Antibody (clone PGT121) | ELISA, Neut | Human IgG |
PABS-0064 | Human Anti-HIV ENV Recombinant Antibody (Clone GEP 1) | ELISA, Neut, FuncS | Human IgG |
VS-0723-XY16 | Recombinant Human Anti-HIV Env Antibody (clone PC39-1) | ELISA, BLI, Neut | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-323-F(E) | Recombinant Anti-HIV Env Antibody Fab Fragment | IF, FC, FuncS | Fab |
PFBS-0064 | Human Anti-HIV ENV Recombinant Antibody (Clone GEP 1); Fab Fragment | ELISA, Neut, FuncS | Human Fab |
PFBS-0113 | Human Anti-HIV ENV Recombinant Antibody (Clone PG9_N100FY); Fab Fragment | ELISA, Neut, FuncS | Human Fab |
PFBS-0125 | Mouse Anti-HIV Env Recombinant Antibody (Clone vFP25.18); Fab Fragment | ELISA, Neut, FuncS | Mouse Fab |
PABJ-0117-F(E) | Rabbit Anti-HIV Env Recombinant Antibody (clone 1C2); Fab fragment | ELISA, Neut | Rabbit Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-323-S(P) | Recombinant Anti-HIV Env Antibody scFv Fragment | IP, IF, Biosensors, FuncS | scFv |
PSBL-505 | Human Anti-HIV Env Recombinant Antibody (clone 10-1074); scFv Fragment | ELISA, Neut | Human scFv |
PSBL-506 | Human Anti-HIV Env Recombinant Antibody (clone PGT121); scFv Fragment | ELISA, Neut | Human scFv |
PSBS-0064 | Human Anti-HIV ENV Recombinant Antibody (Clone GEP 1); scFv Fragment | ELISA, Neut, FuncS | Human scFv |
PABJ-0117-S(P) | Rabbit Anti-HIV Env Recombinant Antibody (clone 1C2); scFv Fragment | ELISA, Neut | Rabbit scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
MHC-YC167 | A*24:02/Human Immunodeficiency virus 1 Envelope glycoprotein (RYLRDQQLL) MHC Pentamer | FCM |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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