Mouse Anti-H2A-H2B-DNA Recombinant Antibody (clone PRl-3) (CAT#: FAMAB-0170CQ)

Recombinant Mouse Antibody clone PRl-3, which is specific to H2A-H2B-DNA. PRl-3 mAb reacts with H2A-H2B-DNA as strongly as with whole nucleosomes.


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ELISA

Figure 1 Binding specificities of nucleosome-reactive mAbs.

Figure 1 Binding specificities of nucleosome-reactive mAbs.

mAb were tested by ELISA against nucleosomes, native DNA or HZA-H2B-DNA that were adsorbed onto poly-L-lysine-coated plates.

Monestier, M., & Novick, K. E. (1996). Specificities and genetic characteristics of nucleosome-reactive antibodies from autoimmune mice. Molecular immunology, 33(1), 89–99.

IF

Figure 2 Immunofluorescence staining of HEp-2 cells by mAb PRl-3.

Figure 2 Immunofluorescence staining of HEp-2 cells by mAb PRl-3.

All six nucleosome-reactive mAb in this study gave the same pattern. mAb was used at 20 ug/ml in PBS-BSA.

Monestier, M., & Novick, K. E. (1996). Specificities and genetic characteristics of nucleosome-reactive antibodies from autoimmune mice. Molecular immunology, 33(1), 89–99.


Specifications

  • Host Species
  • Mouse
  • Type
  • Mouse IgG2a, κ
  • Specificity
  • H2A-H2B-DNA
  • Clone
  • PRl-3
  • Applications
  • ELISA, IF
  • Related Disease
  • Systemic lupus erythematosus (SLE)

Product Property

  • Purity
  • >95% as determined by SDS-PAGE and HPLC analysis
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

  • Alternative Names
  • H2A-H2B-DNA

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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