Recombinant Mouse Antibody clone PRl-3, which is specific to H2A-H2B-DNA. PRl-3 mAb reacts with H2A-H2B-DNA as strongly as with whole nucleosomes.
Figure 1 Binding specificities of nucleosome-reactive mAbs.
mAb were tested by ELISA against nucleosomes, native DNA or HZA-H2B-DNA that were adsorbed onto poly-L-lysine-coated plates.
Monestier, M., & Novick, K. E. (1996). Specificities and genetic characteristics of nucleosome-reactive antibodies from autoimmune mice. Molecular immunology, 33(1), 89–99.
Figure 2 Immunofluorescence staining of HEp-2 cells by mAb PRl-3.
All six nucleosome-reactive mAb in this study gave the same pattern. mAb was used at 20 ug/ml in PBS-BSA.
Monestier, M., & Novick, K. E. (1996). Specificities and genetic characteristics of nucleosome-reactive antibodies from autoimmune mice. Molecular immunology, 33(1), 89–99.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
FAMAB-0168CQ | Mouse Anti-H2A-H2B-DNA Recombinant Antibody (clone LG8-1) | ELISA, IF | Mouse IgG2b, κ |
FAMAB-0169CQ | Mouse Anti-H2A-H2B-DNA Recombinant Antibody (clone MRB4) | ELISA, IF | Mouse IgG2a, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
FAMAB-0168CQ-F(E) | Mouse Anti-H2A-H2B-DNA Recombinant Antibody (clone LG8-1); Fab Fragment | ELISA, IF | Mouse Fab |
FAMAB-0169CQ-F(E) | Mouse Anti-H2A-H2B-DNA Recombinant Antibody (clone MRB4); Fab Fragment | ELISA, IF | Mouse Fab |
FAMAB-0170CQ-F(E) | Mouse Anti-H2A-H2B-DNA Recombinant Antibody (clone PRl-3); Fab Fragment | ELISA, IF | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
FAMAB-0168CQ-S(P) | Mouse Anti-H2A-H2B-DNA Recombinant Antibody (clone LG8-1); scFv Fragment | ELISA, IF | Mouse scFv |
FAMAB-0169CQ-S(P) | Mouse Anti-H2A-H2B-DNA Recombinant Antibody (clone MRB4); scFv Fragment | ELISA, IF | Mouse scFv |
FAMAB-0170CQ-S(P) | Mouse Anti-H2A-H2B-DNA Recombinant Antibody (clone PRl-3); scFv Fragment | ELISA, IF | Mouse scFv |
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