This product is a human antibody targeting P. falciparum antigens. This antibody can be tested in several assays including ELISA, WB, and IP. This antibody may be suitable candidate for the development of a malaria vaccine.
Figure 1 Reactivity and functional assays of MGC and MGD antibodies.
MGD21 staining of 3D7 IE that were enriched or depleted of MGD21 reactivity (n = 3 independent experiments).
Tan, J., Pieper, K., Piccoli, L., Abdi, A., Foglierini, M., Geiger, R., ... & Bejon, P. (2016). A LAIR1 insertion generates broadly reactive antibodies against malaria variant antigens. Nature, 529(7584), 105-109.
Figure 2 Reactivity and functional assays of MGC and MGD antibodies.
Western blot showing MGD21 binding to IP prepared from 9605-MGD21- and 9605-MGD21+ IE (representative of n = 2 independent experiments).
Tan, J., Pieper, K., Piccoli, L., Abdi, A., Foglierini, M., Geiger, R., ... & Bejon, P. (2016). A LAIR1 insertion generates broadly reactive antibodies against malaria variant antigens. Nature, 529(7584), 105-109.
Figure 3 Reactivity and functional assays of MGC and MGD antibodies.
Binding of MGD21 to CHO cells transfected with RIFINs (PF3D7_1400600 and PF3D7_0100200), a RIFIN chimera containing the constant region of PF3D7_0100200 and the variable region of PF3D7_1400600 (PF3D7_0100200c_1400600v), or the inverse chimera (PF3D7_1400600c_0100200v) (n = 1).
Tan, J., Pieper, K., Piccoli, L., Abdi, A., Foglierini, M., Geiger, R., ... & Bejon, P. (2016). A LAIR1 insertion generates broadly reactive antibodies against malaria variant antigens. Nature, 529(7584), 105-109.
Figure 4 Reactivity and functional assays of MGD antibodies.
Agglutinates of 3D7- MGD21+ IE formed by MGD21.
Tan, J., Pieper, K., Piccoli, L., Abdi, A., Foglierini, M., Geiger, R., ... & Bejon, P. (2016). A LAIR1 insertion generates broadly reactive antibodies against malaria variant antigens. Nature, 529(7584), 105-109.
Figure 5 Reactivity and functional assays of MGC and MGD antibodies.
Opsonic phagocytosis of 11019-MGD21+ IE by monocytes (n = 2). The IE were stained with DAPI, which was quantified in monocytes as a measure of phagocytosis.
Tan, J., Pieper, K., Piccoli, L., Abdi, A., Foglierini, M., Geiger, R., ... & Bejon, P. (2016). A LAIR1 insertion generates broadly reactive antibodies against malaria variant antigens. Nature, 529(7584), 105-109.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-738 | Recombinant Anti-P. falciparum Antibody | WB, FC, FuncS | IgG |
MHH-738 | Recombinant Human Anti-P. falciparum Antibody | WB, IF, FuncS | IgG |
PABC-371 | Recombinant Human Anti-P. falciparum Antibody (MGD21) | FuncS, ELISA, IP, WB | Human IgG |
FAMAB-0004WJ | Human Anti-P. falciparum Recombinant Antibody (clone MGD34) | ELISA, WB, IP | Human IgG1 |
FAMAB-0077WJ | Human Anti-P. falciparum Recombinant Antibody (clone MGC34) | ELISA, WB, IP | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-738-F(E) | Recombinant Anti-P. falciparum Antibody Fab Fragment | Neut, IF, FuncS | Fab |
MHH-738-F(E) | Recombinant Human Anti-P. falciparum Antibody Fab Fragment | ELISA, IF, FuncS | Fab |
PFBC-371 | Recombinant Human Anti-P. falciparum Antibody Fab Fragment (MGD21) | ELISA, IP, WB | Human Fab |
FAMAB-0003WJ-F(E) | Human Anti-P. falciparum Recombinant Antibody (clone MGD21); Fab Fragment | ELISA, WB, IP | Human Fab |
FAMAB-0077WJ-F(E) | Human Anti-P. falciparum Recombinant Antibody (clone MGC34); Fab Fragment | ELISA, WB, IP | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-012CT | Recombinant Mouse Anti-Plasmodium falciparum Antibody | Dot, ELISA, WB |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBC-371 | Recombinant Human Anti-P. falciparum Antibody scFv Fragment (MGD21) | ELISA, IP, WB | Human scFv |
FAMAB-0003WJ-S(P) | Human Anti-P. falciparum Recombinant Antibody (clone MGD21); scFv Fragment | ELISA, WB, IP | Human scFv |
FAMAB-0004WJ-S(P) | Human Anti-P. falciparum Recombinant Antibody (clone MGD34); scFv Fragment | ELISA, WB, IP | Human scFv |
FAMAB-0005WJ-S(P) | Human Anti-P. falciparum Recombinant Antibody (clone MGD39); scFv Fragment | ELISA, WB, IP | Human scFv |
FAMAB-0077WJ-S(P) | Human Anti-P. falciparum Recombinant Antibody (clone MGC34); scFv Fragment | ELISA, WB, IP | Human scFv |
There are currently no Customer reviews or questions for FAMAB-0003WJ. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.