Recombinant Human Anti-P. falciparum Antibody (MGD21) (CAT#: PABC-371)
This product is a recombinant Human antibody that can recognize P. falciparum.
Specific Inquiry
FuncS
Figure 1 NK-dependent lysis of RIFIN+ iRBCs in the presence of the RIFIN-specific human monoclonal Ab MGD21.
(A) Staining of RBCs infected with a P.f. 3D7 strain enriched for expression of a RIFIN family member with human monoclonal Ab MGD21 (green) or variant MGD21-LALA (red). The shaded histogram represents staining with AF488-conjugated anti-human IgG (H + L) antiserum alone. (B) Lysis of RIFIN+ iRBCs incubated for 6 hr in the absence of NK cells or at an NK to iRBC ratio of 5:1 in presence or absence of MGD21 or MGD21 LALA Abs.
Arora, G., Hart, G. T., Manzella-Lapeira, J., Doritchamou, J. Y., Narum, D. L., Thomas, L. M., ... & Miller, L. H. (2018). NK cells inhibit Plasmodium falciparum growth in red blood cells via antibody-dependent cellular cytotoxicity. Elife, 7, e36806.
Specifications
- Host Species
- Human
- Type
- Human IgG
- Species Reactivity
- P. falciparum
- Clone
- MGD21
- Applications
- FuncS, ELISA, IP, WB
- Related Disease
- Malaria
Product Property
- Purity
- >95% as determined by analysis by SDS-PAGE
- Storage
- Store at -20°C for long-term storage. Avoid freeze/thaw cycles.
Applications
- Application Notes
- Antibody MGD21 has been reported in the application of Functional Assay, Enzyme-linked Immunosorbent Assay, Immunoprecipitation and Western Blot. It's recommended that the optimal antibody concentration, dilution, incubition time etc. be carefully titrated in specific assays. In hemoglobin release assay, the recommended concentration of MGD21 and MGD21-LALA antibodies is 0.2 mg/ml.
Target
- Alternative Names
- Plasmodium falciparum; P. falciparum
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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IgG Antibody Products
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IgM Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-738 | Recombinant Anti-P. falciparum Antibody | WB, FC, FuncS | IgG |
| MHH-738 | Recombinant Human Anti-P. falciparum Antibody | WB, IF, FuncS | IgG |
| FAMAB-0003WJ | Human Anti-P. falciparum Recombinant Antibody (FAMAB-0003WJ) | FC, WB, IF, ADCC | Human IgG1 |
| FAMAB-0004WJ | Human Anti-P. falciparum Recombinant Antibody (FAMAB-0004WJ) | ELISA, WB, IP | Human IgG1 |
| FAMAB-0077WJ | Human Anti-P. falciparum Recombinant Antibody (clone MGC34) | ELISA, WB, IP | Human IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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