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ANP32B
Multifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Required for the progression from the G1 to the S phase. Anti-apoptotic protein which functions as a caspase-3 inhibitor. Has no phosphatase 2A (PP2A) inhibitor activity (By similarity). Exhibits histone chaperone properties, stimulating core histones to assemble into a nucleosome.
Protein class
Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Erythroid cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Interacts with histones H3 and H4 (PubMed:20538007). Interacts with KLF5; this interaction induces promoter region-specific histone incorporation and inhibition of histone acetylation by ANP32B (PubMed:18039846). (Microbial infection) Interacts with Sendai virus protein M. (Microbial infection) Interacts with Measles virus protein M. (Microbial infection) Interacts with Hendra virus protein M; this interaction promotes nuclear localization of M. (Microbial infection) Interacts with influenza virus B protein PB2; this interaction strongly supports influenza B virus replication.
Molecular function
Chaperone
More Types Infomation
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- Derivation: Phage display library screening
- Species Reactivity: Mouse, Rat, Human
- Type: Rabbit IgG
- Application: WB, IHC-P, IF, FC
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- Species Reactivity: Human, Rat
- Type: Rabbit IgG
- Application: WB, IHC-Fr, IHC-P, IF
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For Research Use Only. Not For Clinical Use.