Rabbit Anti-ANP32B Recombinant Antibody (clone R03-6H2) (CAT#: VS3-FY1830)

• Immunogen
• Synthetic peptide of human PHAPI2

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human and Rat ANP32B

• Species Reactivity
• Human, Rat

• Clone
• R03-6H2

• Applications
• Western Blot, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Immunofluorescence

• MW
• The calculated weight of the target protein is approximately 29 kDa, while the observed molecular weight stands at 29 kDa.

• Related Disease
• Human colon cancer tissue

• Purification
• Affinity Purified

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/1000
  Immunohistochemistry: 1/50-1/100
  Immunofluorescence: 1/50-1/200

• Alternative Names
• Acidic Nuclear Phosphoprotein 32 Family Member B; Acidic Protein Rich In Leucines; Acidic (Leucine-Rich) Nuclear Phosphoprotein 32 Family, Member B; Putative HLA-DR-Associated Protein I-2; Silver-Stainable Protein SSP29; PHAPI2; APRIL; Acidic Leucine-Rich Nuclear Phosphoprotein 32 Family Member B; SSP29

• Gene ID
• 10541

• UniProt ID
• Q92688

• Sequence Similarities
• Belongs to the ANP32 family.

• Cellular Localization
• Cytoplasm, Nucleus

• Post Translation Modifications
• Some glutamate residues are glycylated by TTLL8.
  This modification occurs exclusively on glutamate residues and results in a glycine chain on the gamma-carboxyl group ().
  (Q92688-AN32B_HUMAN)
  Directly cleaved by caspase-3/CASP3. (Q92688-AN32B_HUMAN)
  Ubiquitination at Lys86 and Lys99 (NX_Q92688 [NX_Q92688-1])
  Modification sites at PhosphoSitePlus (Q92688)
  Glycosylation from GlyGen (Q92688) 1 site, 1 O-linked glycan (1 site)

• Protein Refseq
• NP_006392.1

• Function
• As negative regulator of caspase-3-dependent apoptosis, may act as an antagonist of ANP32A in regulating tissue homeostasis.
  Exhibits histone chaperone properties, able to recruit histones to certain promoters, thus regulating the transcription of specific genes.
  Also plays an essential role in the nucleocytoplasmic transport of specific mRNAs via the uncommon nuclear mRNA export receptor XPO1/CRM1.

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Secondary Antibody

• 2ND-054CQ
• Goat Anti-Rabbit IgG Antibody, R-PE

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-055CQ
• Chicken Anti-Rabbit IgG (H&L) Antibody

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