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LIN28B
The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fetal liver, placenta, and in primary human tumors and cancer cell lines. It is negatively regulated by microRNAs that target sites in the 3' UTR, and overexpression of this gene in primary tumors is linked to the repression of let-7 family of microRNAs and derepression of let-7 targets, which facilitates cellular transformation.
Predicted location
Intracellular
Single cell type specificity
Group enriched (Extravillous trophoblasts, Cytotrophoblasts, Syncytiotrophoblasts, Excitatory neurons, Early spermatids, Late spermatids)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (AF22, BEWO, Hep G2, K-562, NTERA-2, SuSa)
Molecular function
RNA-binding
More Types Infomation
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- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: WB, IF, IHC
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, ICC, IF, IP, FC
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: WB, ICC, IHC
- Mouse Anti-LIN28B Recombinant Antibody (VS3-WK1043) (VS3-WK1043)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB
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For Research Use Only. Not For Clinical Use.