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PVRIG

Cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding.
Predicted location

Membrane

Single cell type specificity

Cell type enhanced (T-cells, NK-cells, B-cells, Horizontal cells, granulocytes, Plasma cells)

Immune cell specificity

Group enriched (MAIT T-cell, NK-cell, gdT-cell, memory CD8 T-cell, naive CD4 T-cell, naive CD8 T-cell, memory CD4 T-cell, memory B-cell, T-reg, naive B-cell)

Cell line specificity

Group enriched (Daudi, JURKAT, MOLT-4, U-698)

Interaction

Interacts with NECTIN2, hence competing with CD226.

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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